Immunohistochemistry of the blood group A, B, H isoantigens and Oxford Ca antigen as prognostic markers for stage IB squamous cell carcinoma of the cervix

C. W. Alexander, Seng‐jaw ‐j Soong, Hugh M. Shingleton, Hazel Gore, James A. Wilkerson, Kenneth D. Hatch, Dale Phillips, James R. Dollar

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Currently, there is lack of a histologic classification of squamous cell carcinoma of the cervix that correlates significantly with patient survival. This study investigated the survival predictive value of two immuno‐histochemical markers, the blood group A,B,H isoantigens and the Oxford Ca antigen, on conventional histologic sections of tumor tissues from 85 surgically treated patients with Stage IB squamous cell cervical cancer. The results indicated that the two antigens are two distinct markers, neither of which correlates with tumor grade. The expression of the A,B,H isoantigens is significantly related to patient survival after adjustment for the depth of stromal invasion of the tumor, whereas the Oxford Ca antigen has no survival predictive value.

Original languageEnglish (US)
Pages (from-to)2435-2439
Number of pages5
JournalCancer
Volume58
Issue number11
DOIs
StatePublished - Dec 1 1986
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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