Immunologic influences on emotion regulation

Andrew H. Miller, Lucile Capuron, Charles L Raison

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Recent data document meaningful interactions between the immune system and the brain that provide the foundation for considering the potential influence of immunologic processes on emotion regulation. Studies from both laboratory animals and humans demonstrate that cytokine signals can access the brain and in turn lead to profound changes in neurochemistry, neuroendocrinology and behavior. Interestingly, data suggest that the behavioral and physiological consequences of stressful life experiences may also derive in part from the effects of stress on the immune response. The extant literature on brain-immune interactions is reviewed herein with special emphasis on data derived from patients undergoing treatment with the cytokine, interferon alpha. Consideration is also given to the mechanisms by which cytokines induce behavioral change, including an examination of the differential mechanisms that may be involved in cytokine effects on mood and cognition versus cytokine effects on neurovegetative function. Finally, implications of these findings are examined both from an evolutionary perspective and in terms of their relevance for treatment of patients with neuropsychiatric disorders.

Original languageEnglish (US)
Pages (from-to)325-333
Number of pages9
JournalClinical Neuroscience Research
Volume4
Issue number5-6 SPEC. ISS.
DOIs
StatePublished - May 2005
Externally publishedYes

Fingerprint

Emotions
Cytokines
Brain
Neuroendocrinology
Neurochemistry
Life Change Events
Laboratory Animals
Interferon-alpha
Cognition
Immune System
Therapeutics

Keywords

  • Anxiety
  • Cytokines
  • Depression
  • Fatigue
  • Immune system
  • Interferon-alpha
  • Stress

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Neurology
  • Neuropsychology and Physiological Psychology

Cite this

Immunologic influences on emotion regulation. / Miller, Andrew H.; Capuron, Lucile; Raison, Charles L.

In: Clinical Neuroscience Research, Vol. 4, No. 5-6 SPEC. ISS., 05.2005, p. 325-333.

Research output: Contribution to journalArticle

Miller, Andrew H. ; Capuron, Lucile ; Raison, Charles L. / Immunologic influences on emotion regulation. In: Clinical Neuroscience Research. 2005 ; Vol. 4, No. 5-6 SPEC. ISS. pp. 325-333.
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