Immunologic studies and clinical follow-up HB<inf>s</inf>Ag-positive polyarteritis nodosa

Thomas D Boyer, Myron J. Tong, Jorge Rakela, Telfer B. Reynolds

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Three patients with hepatitis B surface antigen (HB<inf>s</inf>Ag)-positive polyarteritis nodosa (PAN) who are clinically well 41/2-51/2 years after their initial illnesses are described. In each case electron microscopic studies demonstrated the presence of aggregates of HB<inf>s</inf>Ag in both acute and quiescent phase sera. One patient had a lower circulating HB<inf>s</inf>Ag titer during the acute illness, while no change in serial HB<inf>s</inf>Ag titers was observed in the other two patients. Two of the three patients showed lymphocyte transformation to purified HB<inf>s</inf>Ag during the quiescent phase of the PAN. The role of immune complexes in the pathogenesis of HB<inf>s</inf>Ag-positive PAN is discussed.

Original languageEnglish (US)
Pages (from-to)497-501
Number of pages5
JournalThe American Journal of Digestive Diseases
Volume22
Issue number6
DOIs
StatePublished - 1977
Externally publishedYes

Fingerprint

Polyarteritis Nodosa
Hepatitis B Surface Antigens
Lymphocyte Activation
Antigen-Antibody Complex
Electrons
Serum

ASJC Scopus subject areas

  • Gastroenterology
  • Medicine(all)

Cite this

Immunologic studies and clinical follow-up HB<inf>s</inf>Ag-positive polyarteritis nodosa. / Boyer, Thomas D; Tong, Myron J.; Rakela, Jorge; Reynolds, Telfer B.

In: The American Journal of Digestive Diseases, Vol. 22, No. 6, 1977, p. 497-501.

Research output: Contribution to journalArticle

Boyer, Thomas D ; Tong, Myron J. ; Rakela, Jorge ; Reynolds, Telfer B. / Immunologic studies and clinical follow-up HB<inf>s</inf>Ag-positive polyarteritis nodosa. In: The American Journal of Digestive Diseases. 1977 ; Vol. 22, No. 6. pp. 497-501.
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