Immunological studies of male homosexuals with the prodrome of the acquired immunodeficiency syndrome (AIDS).

E. M. Hersh, J. M. Reuben, P. W. Mansell, A. Rios, G. R. Newell, J. Frank, A. L. Goldstein

Research output: Contribution to journalArticle

Abstract

Homosexual patients who mainly had the prodrome of the syndrome of opportunistic infection and Kaposi's sarcoma were studied immunologically. Patients showed diminished delayed hypersensitivity to recall antigens, diminished lymphocyte blastogenic responses, a suppressor cell for lymphocyte proliferative responses, low helper cells and an inverted helper:suppressor ratio. The patients had low levels of adherent monocytes. NK cell activity and antibody dependent cellular cytotoxicity were normal. Virtually all patients showed elevated serum thymosin alpha 1 levels and elevated serum lysozyme levels. The most consistent findings were the low helper cells, inverted helper:suppressor ratio and elevated serum thymosin alpha 1 and lysozyme. The patients with the prodrome should be subjected to therapeutic research with immunorestorative drugs.

Original languageEnglish (US)
Pages (from-to)285-293
Number of pages9
JournalAdvances in experimental medicine and biology
Volume166
StatePublished - Dec 1 1983

    Fingerprint

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Hersh, E. M., Reuben, J. M., Mansell, P. W., Rios, A., Newell, G. R., Frank, J., & Goldstein, A. L. (1983). Immunological studies of male homosexuals with the prodrome of the acquired immunodeficiency syndrome (AIDS). Advances in experimental medicine and biology, 166, 285-293.