Immunomodulation by immunopeptides and autoantibodies in aging, autoimmunity, and infection

J. J. Marchalonis, S. F. Schluter, R. T. Sepulveda, R. R. Watson, D. F. Larson

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The operation of the immune system is a complex orchestration of specific self and non-self-recognition capacities mediated by cells of the innate system acting in coordination with T and B lymphocytes in a series of processes modulated by cytokines. We provide evidence for a natural immunomodulatory system involving autoantibodies directed against a controlling segment of T cell receptor Vβ chains that downregulate production of stimulatory cytokines balanced by the peptides which in turn upregulate inflammatory activities mediated by TH1-type helper cells. TCR Vβ-derived peptides effective in retrovirally induced immunosupression could also reverse the effects of immunosenescence in aged mice by restoring the balance of TH1- and TH2-type immunity and the resistance of the animals to cardiac pathology caused by infection with coxsackievirus. An unexpected finding was an adaptive role of the T cells from peptide-treated mice in remodeling damaged hearts by increasing net collagen synthesis by cardiac fibroblasts.

Original languageEnglish (US)
Pages (from-to)247-259
Number of pages13
JournalAnnals of the New York Academy of Sciences
Volume1057
DOIs
StatePublished - Jan 1 2005

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Keywords

  • Cardiopathology
  • Coxsackievirus
  • Cytokines
  • Immunosenescence
  • Retrovirus
  • T cell receptors
  • TCR Vβ
  • TH1
  • TH2

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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