Immunomodulation by pycnogenol® in retrovirus-infected or ethanol-fed mice

Jeanne E. Cheshier, Sussan Ardestani-Kaboudanian, Bailin Liang, Mohsen Araghiniknam, Sangbun Chung, Lisa Lane, Anabell Castro, Ronald R. Watson

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Pycnogenol® is a commercial mixture of bioflavonoids that exhibits antioxidative activity. The effects of dietary pycnogenol on immune dysfunction in normal mice as well as those fed ethanol or infected with the LP-BM5 murine retrovirus were determined. The ethanol consumption and retrovirus infection cause abnormalities in the function and/or structure of a broad array of cells involved in humoral and cellular immunity. Pycnogenol enhanced in vitro IL-2 production by mitogen-stimulated splenocytes if its production was suppressed in ethanolfed or retrovirus-infected mice. Mitogenesis of splenocytes did not show a significant change in mice treated with pycnogenol. It reduced the elevated levels of interleukin-6 produced in vitro by cells from retrovirus infected mice and IL-10 secreted by spleen cells from mice consuming ethanol. Natural killer cell cytotoxicity was increased with pycnogenol treatment.

Original languageEnglish (US)
Pages (from-to)PL87-PL96
JournalLife Sciences
Volume58
Issue number5
DOIs
StatePublished - Dec 22 1995

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Keywords

  • ethanol-fed mice
  • immune dysfunction
  • pycnogenol
  • retrovirus-infected mice

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Cheshier, J. E., Ardestani-Kaboudanian, S., Liang, B., Araghiniknam, M., Chung, S., Lane, L., Castro, A., & Watson, R. R. (1995). Immunomodulation by pycnogenol® in retrovirus-infected or ethanol-fed mice. Life Sciences, 58(5), PL87-PL96. https://doi.org/10.1016/0024-3205(95)02303-8