Immunomodulation in humans caused by beta-carotene and vitamin A

Rao H. Prabhala, Harinder S. Garewal, Frank L. Meyskens, Ronald R Watson

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Carotenoids and retinoids can stimulate some human immune responses. These include cytoine release with anti-tumor cell activity, increased natural killer cells and activated lymphocytes after both in vitro and in vivo treatment with beta carotene. Such stimulations seem only partly due to retinoids formed from carotenoid metabolism and may be due to effects caused by the structure of beta carotene. Changes in immune functions could explain in part the cancer resistance provided by high carotenoid or retinoid intakes in animals.

Original languageEnglish (US)
Pages (from-to)1473-1486
Number of pages14
JournalNutrition Research
Volume10
Issue number12
DOIs
StatePublished - 1990

Fingerprint

Immunomodulation
Retinoids
beta Carotene
Carotenoids
Vitamin A
Natural Killer Cells
Neoplasms
Lymphocytes
Therapeutics

Keywords

  • activated lymphocytes
  • beta carotene
  • cancer
  • natural killer cells

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Immunomodulation in humans caused by beta-carotene and vitamin A. / Prabhala, Rao H.; Garewal, Harinder S.; Meyskens, Frank L.; Watson, Ronald R.

In: Nutrition Research, Vol. 10, No. 12, 1990, p. 1473-1486.

Research output: Contribution to journalArticle

Prabhala, Rao H. ; Garewal, Harinder S. ; Meyskens, Frank L. ; Watson, Ronald R. / Immunomodulation in humans caused by beta-carotene and vitamin A. In: Nutrition Research. 1990 ; Vol. 10, No. 12. pp. 1473-1486.
@article{e5f96255460a4b049c0997af69b1b941,
title = "Immunomodulation in humans caused by beta-carotene and vitamin A",
abstract = "Carotenoids and retinoids can stimulate some human immune responses. These include cytoine release with anti-tumor cell activity, increased natural killer cells and activated lymphocytes after both in vitro and in vivo treatment with beta carotene. Such stimulations seem only partly due to retinoids formed from carotenoid metabolism and may be due to effects caused by the structure of beta carotene. Changes in immune functions could explain in part the cancer resistance provided by high carotenoid or retinoid intakes in animals.",
keywords = "activated lymphocytes, beta carotene, cancer, natural killer cells",
author = "Prabhala, {Rao H.} and Garewal, {Harinder S.} and Meyskens, {Frank L.} and Watson, {Ronald R}",
year = "1990",
doi = "10.1016/S0271-5317(05)80139-3",
language = "English (US)",
volume = "10",
pages = "1473--1486",
journal = "Nutrition Research",
issn = "0271-5317",
publisher = "Elsevier Inc.",
number = "12",

}

TY - JOUR

T1 - Immunomodulation in humans caused by beta-carotene and vitamin A

AU - Prabhala, Rao H.

AU - Garewal, Harinder S.

AU - Meyskens, Frank L.

AU - Watson, Ronald R

PY - 1990

Y1 - 1990

N2 - Carotenoids and retinoids can stimulate some human immune responses. These include cytoine release with anti-tumor cell activity, increased natural killer cells and activated lymphocytes after both in vitro and in vivo treatment with beta carotene. Such stimulations seem only partly due to retinoids formed from carotenoid metabolism and may be due to effects caused by the structure of beta carotene. Changes in immune functions could explain in part the cancer resistance provided by high carotenoid or retinoid intakes in animals.

AB - Carotenoids and retinoids can stimulate some human immune responses. These include cytoine release with anti-tumor cell activity, increased natural killer cells and activated lymphocytes after both in vitro and in vivo treatment with beta carotene. Such stimulations seem only partly due to retinoids formed from carotenoid metabolism and may be due to effects caused by the structure of beta carotene. Changes in immune functions could explain in part the cancer resistance provided by high carotenoid or retinoid intakes in animals.

KW - activated lymphocytes

KW - beta carotene

KW - cancer

KW - natural killer cells

UR - http://www.scopus.com/inward/record.url?scp=0025598267&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025598267&partnerID=8YFLogxK

U2 - 10.1016/S0271-5317(05)80139-3

DO - 10.1016/S0271-5317(05)80139-3

M3 - Article

VL - 10

SP - 1473

EP - 1486

JO - Nutrition Research

JF - Nutrition Research

SN - 0271-5317

IS - 12

ER -