Immunomodulation in humans caused by beta-carotene and vitamin A

Rao H. Prabhala; Harinder S. Garewal; Frank L. Meyskens; Ronald R. Watson

doi:10.1016/S0271-5317(05)80139-3

Immunomodulation in humans caused by beta-carotene and vitamin A

Rao H. Prabhala, Harinder S. Garewal, Frank L. Meyskens, Ronald R. Watson

Health Promotion Sciences

Research output: Contribution to journal › Review article › peer-review

23 Scopus citations

Abstract

Carotenoids and retinoids can stimulate some human immune responses. These include cytoine release with anti-tumor cell activity, increased natural killer cells and activated lymphocytes after both in vitro and in vivo treatment with beta carotene. Such stimulations seem only partly due to retinoids formed from carotenoid metabolism and may be due to effects caused by the structure of beta carotene. Changes in immune functions could explain in part the cancer resistance provided by high carotenoid or retinoid intakes in animals.

Original language	English (US)
Pages (from-to)	1473-1486
Number of pages	14
Journal	Nutrition Research
Volume	10
Issue number	12
DOIs	https://doi.org/10.1016/S0271-5317(05)80139-3
State	Published - Dec 1990

Keywords

activated lymphocytes
beta carotene
cancer
natural killer cells

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology
Nutrition and Dietetics

Access to Document

10.1016/S0271-5317(05)80139-3

Fingerprint Dive into the research topics of 'Immunomodulation in humans caused by beta-carotene and vitamin A'. Together they form a unique fingerprint.

Cite this

@article{e5f96255460a4b049c0997af69b1b941,

title = "Immunomodulation in humans caused by beta-carotene and vitamin A",

abstract = "Carotenoids and retinoids can stimulate some human immune responses. These include cytoine release with anti-tumor cell activity, increased natural killer cells and activated lymphocytes after both in vitro and in vivo treatment with beta carotene. Such stimulations seem only partly due to retinoids formed from carotenoid metabolism and may be due to effects caused by the structure of beta carotene. Changes in immune functions could explain in part the cancer resistance provided by high carotenoid or retinoid intakes in animals.",

keywords = "activated lymphocytes, beta carotene, cancer, natural killer cells",

author = "Prabhala, {Rao H.} and Garewal, {Harinder S.} and Meyskens, {Frank L.} and Watson, {Ronald R.}",

year = "1990",

month = dec,

doi = "10.1016/S0271-5317(05)80139-3",

language = "English (US)",

volume = "10",

pages = "1473--1486",

journal = "Nutrition Research",

issn = "0271-5317",

publisher = "Elsevier Inc.",

number = "12",

}

TY - JOUR

T1 - Immunomodulation in humans caused by beta-carotene and vitamin A

AU - Prabhala, Rao H.

AU - Garewal, Harinder S.

AU - Meyskens, Frank L.

AU - Watson, Ronald R.

PY - 1990/12

Y1 - 1990/12

N2 - Carotenoids and retinoids can stimulate some human immune responses. These include cytoine release with anti-tumor cell activity, increased natural killer cells and activated lymphocytes after both in vitro and in vivo treatment with beta carotene. Such stimulations seem only partly due to retinoids formed from carotenoid metabolism and may be due to effects caused by the structure of beta carotene. Changes in immune functions could explain in part the cancer resistance provided by high carotenoid or retinoid intakes in animals.

AB - Carotenoids and retinoids can stimulate some human immune responses. These include cytoine release with anti-tumor cell activity, increased natural killer cells and activated lymphocytes after both in vitro and in vivo treatment with beta carotene. Such stimulations seem only partly due to retinoids formed from carotenoid metabolism and may be due to effects caused by the structure of beta carotene. Changes in immune functions could explain in part the cancer resistance provided by high carotenoid or retinoid intakes in animals.

KW - activated lymphocytes

KW - beta carotene

KW - cancer

KW - natural killer cells

UR - http://www.scopus.com/inward/record.url?scp=0025598267&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025598267&partnerID=8YFLogxK

U2 - 10.1016/S0271-5317(05)80139-3

DO - 10.1016/S0271-5317(05)80139-3

M3 - Review article

AN - SCOPUS:0025598267

VL - 10

SP - 1473

EP - 1486

JO - Nutrition Research

JF - Nutrition Research

SN - 0271-5317

IS - 12

ER -

Immunomodulation in humans caused by beta-carotene and vitamin A

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this