Immunopathogenesis of sarcoidosis

Aliya Noor, Kenneth S. Knox

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

The immunopathogenesis of sarcoidosis has been difficult to charaterize given the heterogeneity of disease, the elusiveness of the causative antigen, and the lack of an adequate animal model. However, by examining well-defined clinical cohorts, the interplay between genetic predisposition and immunologic response has been increasingly informative. Technological advances in cellular analysis have allowed researchers to characterize the immune responses important in the maintenance of granulomatous inflammation. Finally, "new" clinical observations such as granuloma responsiveness to targeted biological therapies, sarcoid developing during immune restoration, and the relationship between sarcoidosis and Hepatitis C will provide future insight to the immunopathogenesis of sarcoidosis.

Original languageEnglish (US)
Pages (from-to)250-258
Number of pages9
JournalClinics in Dermatology
Volume25
Issue number3
DOIs
StatePublished - May 1 2007
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology

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