Immunophenotypes in "well-differentiated" lymphoproliferative disorders, with emphasis on small lymphocytic lymphoma

Catherine S Perry, Thomas M. Grogan, Kathleen Fielder, Lynne Richter, Catherine Rangel

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The histologic, immunophenotypic, and clinical findings in 24 cases of "well-differentiated" lymphoproliferative disorders are presented, with an emphasis on small lymphocytic lymphoma (SLL; well-differentiated lymphocytic lymphoma, WDLL). SLL was dignosed in 18 patients, Waldenström's macroglobulinemia in one, mantle zone lymphoma (MZL) in four, and intermediate differentiated lymphocytic lymphoma (IDL) in one. Immunophenotypic analysis revealed one SLL to be of T-cell derivation, while a monoclonal B-cell phenotype was found in the remaining 23 patients; 20 of these neoplasms co-expressed the pan-T-cell antigen Leu-1. This included three of the four patients with MZL and the patient with IDL. All SLLs with pseudofollicular growth centers stained for transferrin receptor. Additionally, a survey of 248 non-Hodgkin's lymphomas of all types revealed four of 70 patients with B-cell large cell lymphoma (LCL; diffuse histiocytic lymphoma, DHL) that also co-expressed the same Leu-1 antigen. Immunoperoxidase study of both frozen tissue sections and cytocentrifuge preparations eliminated the limitations of faint antigen expression and/or interstitial immunoglobulin staining. In addition to detailing the immunophenotype of SLL, the immunologic kinship of MZL/IDL to SLL and the uncommon co-expression of Leu-1 in B-cell LCLs are demonstrated.

Original languageEnglish (US)
Pages (from-to)1126-1136
Number of pages11
JournalHuman Pathology
Volume17
Issue number11
DOIs
StatePublished - 1986
Externally publishedYes

Fingerprint

Mantle-Cell Lymphoma
Lymphoproliferative Disorders
B-Cell Chronic Lymphocytic Leukemia
B-Lymphocytes
CD5 Antigens
T-Lymphocytes
Waldenstrom Macroglobulinemia
Transferrin Receptors
Lymphoma, Large B-Cell, Diffuse
Viral Tumor Antigens
Frozen Sections
Non-Hodgkin's Lymphoma
Immunoglobulins
Lymphoma
Staining and Labeling
Phenotype
Antigens
Growth
Neoplasms

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Immunophenotypes in "well-differentiated" lymphoproliferative disorders, with emphasis on small lymphocytic lymphoma. / Perry, Catherine S; Grogan, Thomas M.; Fielder, Kathleen; Richter, Lynne; Rangel, Catherine.

In: Human Pathology, Vol. 17, No. 11, 1986, p. 1126-1136.

Research output: Contribution to journalArticle

Perry, Catherine S ; Grogan, Thomas M. ; Fielder, Kathleen ; Richter, Lynne ; Rangel, Catherine. / Immunophenotypes in "well-differentiated" lymphoproliferative disorders, with emphasis on small lymphocytic lymphoma. In: Human Pathology. 1986 ; Vol. 17, No. 11. pp. 1126-1136.
@article{8ffa9756eeb34b7487b6db0966e6e2ae,
title = "Immunophenotypes in {"}well-differentiated{"} lymphoproliferative disorders, with emphasis on small lymphocytic lymphoma",
abstract = "The histologic, immunophenotypic, and clinical findings in 24 cases of {"}well-differentiated{"} lymphoproliferative disorders are presented, with an emphasis on small lymphocytic lymphoma (SLL; well-differentiated lymphocytic lymphoma, WDLL). SLL was dignosed in 18 patients, Waldenstr{\"o}m's macroglobulinemia in one, mantle zone lymphoma (MZL) in four, and intermediate differentiated lymphocytic lymphoma (IDL) in one. Immunophenotypic analysis revealed one SLL to be of T-cell derivation, while a monoclonal B-cell phenotype was found in the remaining 23 patients; 20 of these neoplasms co-expressed the pan-T-cell antigen Leu-1. This included three of the four patients with MZL and the patient with IDL. All SLLs with pseudofollicular growth centers stained for transferrin receptor. Additionally, a survey of 248 non-Hodgkin's lymphomas of all types revealed four of 70 patients with B-cell large cell lymphoma (LCL; diffuse histiocytic lymphoma, DHL) that also co-expressed the same Leu-1 antigen. Immunoperoxidase study of both frozen tissue sections and cytocentrifuge preparations eliminated the limitations of faint antigen expression and/or interstitial immunoglobulin staining. In addition to detailing the immunophenotype of SLL, the immunologic kinship of MZL/IDL to SLL and the uncommon co-expression of Leu-1 in B-cell LCLs are demonstrated.",
author = "Perry, {Catherine S} and Grogan, {Thomas M.} and Kathleen Fielder and Lynne Richter and Catherine Rangel",
year = "1986",
doi = "10.1016/S0046-8177(86)80418-X",
language = "English (US)",
volume = "17",
pages = "1126--1136",
journal = "Human Pathology",
issn = "0046-8177",
publisher = "W.B. Saunders Ltd",
number = "11",

}

TY - JOUR

T1 - Immunophenotypes in "well-differentiated" lymphoproliferative disorders, with emphasis on small lymphocytic lymphoma

AU - Perry, Catherine S

AU - Grogan, Thomas M.

AU - Fielder, Kathleen

AU - Richter, Lynne

AU - Rangel, Catherine

PY - 1986

Y1 - 1986

N2 - The histologic, immunophenotypic, and clinical findings in 24 cases of "well-differentiated" lymphoproliferative disorders are presented, with an emphasis on small lymphocytic lymphoma (SLL; well-differentiated lymphocytic lymphoma, WDLL). SLL was dignosed in 18 patients, Waldenström's macroglobulinemia in one, mantle zone lymphoma (MZL) in four, and intermediate differentiated lymphocytic lymphoma (IDL) in one. Immunophenotypic analysis revealed one SLL to be of T-cell derivation, while a monoclonal B-cell phenotype was found in the remaining 23 patients; 20 of these neoplasms co-expressed the pan-T-cell antigen Leu-1. This included three of the four patients with MZL and the patient with IDL. All SLLs with pseudofollicular growth centers stained for transferrin receptor. Additionally, a survey of 248 non-Hodgkin's lymphomas of all types revealed four of 70 patients with B-cell large cell lymphoma (LCL; diffuse histiocytic lymphoma, DHL) that also co-expressed the same Leu-1 antigen. Immunoperoxidase study of both frozen tissue sections and cytocentrifuge preparations eliminated the limitations of faint antigen expression and/or interstitial immunoglobulin staining. In addition to detailing the immunophenotype of SLL, the immunologic kinship of MZL/IDL to SLL and the uncommon co-expression of Leu-1 in B-cell LCLs are demonstrated.

AB - The histologic, immunophenotypic, and clinical findings in 24 cases of "well-differentiated" lymphoproliferative disorders are presented, with an emphasis on small lymphocytic lymphoma (SLL; well-differentiated lymphocytic lymphoma, WDLL). SLL was dignosed in 18 patients, Waldenström's macroglobulinemia in one, mantle zone lymphoma (MZL) in four, and intermediate differentiated lymphocytic lymphoma (IDL) in one. Immunophenotypic analysis revealed one SLL to be of T-cell derivation, while a monoclonal B-cell phenotype was found in the remaining 23 patients; 20 of these neoplasms co-expressed the pan-T-cell antigen Leu-1. This included three of the four patients with MZL and the patient with IDL. All SLLs with pseudofollicular growth centers stained for transferrin receptor. Additionally, a survey of 248 non-Hodgkin's lymphomas of all types revealed four of 70 patients with B-cell large cell lymphoma (LCL; diffuse histiocytic lymphoma, DHL) that also co-expressed the same Leu-1 antigen. Immunoperoxidase study of both frozen tissue sections and cytocentrifuge preparations eliminated the limitations of faint antigen expression and/or interstitial immunoglobulin staining. In addition to detailing the immunophenotype of SLL, the immunologic kinship of MZL/IDL to SLL and the uncommon co-expression of Leu-1 in B-cell LCLs are demonstrated.

UR - http://www.scopus.com/inward/record.url?scp=0023013967&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023013967&partnerID=8YFLogxK

U2 - 10.1016/S0046-8177(86)80418-X

DO - 10.1016/S0046-8177(86)80418-X

M3 - Article

C2 - 3095214

AN - SCOPUS:0023013967

VL - 17

SP - 1126

EP - 1136

JO - Human Pathology

JF - Human Pathology

SN - 0046-8177

IS - 11

ER -