Immunophenotyping in the management of gastric lymphoma

Hugo V. Villar, Randolph Wong, Benjamin Paz, David Bull, Leigh A Neumayer, Thomas Grogan, Catherine S Perry

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Primary gastric lymphoma is a rare tumor in which surgical resection plays a major role in improving the response rate and reducing the incidence of bleeding and perforation after chemotherapy. In 17 consecutive patients, the diagnosis of gastric lymphoma was made by immunophenotyping snapfrozen endoscopic biopsy specimens. All neoplasms were B-cell lymphomas. Pan B surface marker antigens were present in all patients. Levels of Ki-67, a nuclear marker of tumor proliferation, were greater than 45% in two of the four patients who died after progression of their lymphoma. All patients alive had Ki-67 levels of less than 30%. A lower proliferation index, as measured by Ki-67, appears to be associated with better prognosis. Ten of 11 patients treated by resection prior to chemotherapy had no complications. Immunophenotyping is the key in the differential diagnosis when considering malignant lymphoma with gastric carcinoma and benign conditions such as pseudolymphoma.

Original languageEnglish (US)
Pages (from-to)171-176
Number of pages6
JournalAmerican Journal of Surgery
Volume161
Issue number1
DOIs
StatePublished - 1991

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Immunophenotyping
Lymphoma
Pseudolymphoma
Drug Therapy
Differentiation Antigens
B-Cell Lymphoma
Surface Antigens
Tumor Biomarkers
Neoplasms
Stomach
Differential Diagnosis
Familial primary gastric lymphoma
Hemorrhage
Carcinoma
Biopsy
Incidence

ASJC Scopus subject areas

  • Surgery

Cite this

Immunophenotyping in the management of gastric lymphoma. / Villar, Hugo V.; Wong, Randolph; Paz, Benjamin; Bull, David; Neumayer, Leigh A; Grogan, Thomas; Perry, Catherine S.

In: American Journal of Surgery, Vol. 161, No. 1, 1991, p. 171-176.

Research output: Contribution to journalArticle

Villar, Hugo V. ; Wong, Randolph ; Paz, Benjamin ; Bull, David ; Neumayer, Leigh A ; Grogan, Thomas ; Perry, Catherine S. / Immunophenotyping in the management of gastric lymphoma. In: American Journal of Surgery. 1991 ; Vol. 161, No. 1. pp. 171-176.
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