Immunotherapeutic approaches for the treatment of malignant melanoma

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

Clinical and laboratory observations suggest that host immunological responses may occassionally influence the course of melanoma, stimulating the investigation of immunotherapy approaches in this disease. Areas of active investigation have included recombinant cytokines, either alone or in combination with chemotherapeutic regimens or other biological response modifiers, such as vaccines, monoclonal antibodies, dendritic cells and gene therapy. To date, the benefit of these approaches in patients at high-risk of recurrence or advanced disease has been modest. Although many of these novel strategies are limited by weak antigen presentation, tumor-induced tolerance and tumor heterogeneity, it is possible that these approaches will prove more useful when given in combination.

Original languageEnglish (US)
Pages (from-to)1553-1563
Number of pages11
JournalCurrent Opinion in Investigational Drugs
Volume2
Issue number11
StatePublished - Dec 4 2001
Externally publishedYes

Keywords

  • IFNα
  • IL-2
  • Immunotherapy
  • Malignant melanoma
  • Monoclonal antibody
  • Vaccines

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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