Immunotoxicity of poly-drug use: abnormalities in the active and high-affinity CD2 antigen (E-rosette receptor) bearing T-lymphocytes

Bindu S. Nair, Julie R. Erickson, Radhakrishna Pillai, Antonio L Estrada, Ronald R Watson

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Abstract

The E-rosetting profiles of T-cells were studied in 47 subjects with a history of poly-drug and alcohol abuse, and compared with 15 normal controls. No change was evident in numbers of total rosette-forming cells (TRFC). However, there was reduction in active and high-affinity rosette-forming cells (ARFC and HARFC). These two subsets of CD2-antigen-bearing T-cells are considered as immunocompetent surveillance cells. Thus the abnormality associated with them could be due to the combined immunotoxic effects of substance abuse, modulating the immune status of drug users.

Original languageEnglish (US)
Pages (from-to)339-345
Number of pages7
JournalToxicology Letters
Volume57
Issue number3
DOIs
Publication statusPublished - 1991

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Keywords

  • Immunotoxicity
  • Poly-drug abuse
  • T-cell

ASJC Scopus subject areas

  • Toxicology

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