Impact of a winter respiratory virus season on patients with COPD and association with influenza vaccination

Geoffrey J. Gorse, Theresa Z. O'Connor, Stephen L. Young, Michael P Habib, Janet Wittes, Kathleen M. Neuzil, Kristin L. Nichol

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Background: We assessed the effects of an influenza season on patients with COPD. Data from 2,215 veterans in a multicenter, randomized, double-blind influenza vaccine efficacy study were analyzed for changes in spirometric and functional status, comparing patients with laboratory-documented influenza (LDI)-caused illness, non-LDI-caused respiratory illness, or no illness, and for association with influenza vaccination. Methods: Patients received either IM trivalent inactivated influenza virus vaccine (TIV) plus intranasal trivalent, live attenuated, cold-adapted influenza virus vaccine (TC) or TIV plus intranasal placebo (TP). We performed spirometry, measured the chronic lung disease severity index (CLDSI) score to assess functional status and well-being, and tested for influenza virus infection. Results: Worsening in FEV 1, percentage of predicted FEV1, and CLDSI score (p < 0.001) was associated with acute respiratory illness in 585 illnesses including 94 LDI-caused illnesses. LDI-caused illness was more likely to be associated with worsening in FEV1 and CLDSI score acutely than non-LDI-caused illness (p < 0.01). Logistic regression showed acute respiratory illness (odds ratio [OR], 1.78; 95% confidence limit [CL], 1.40 to 2.26) to be associated with worsening in CLDSI score, and receipt of TC (OR, 1.39; 95% CL, 1.10 to 1.74) and no illness (OR, 0.70; 95% CL, 0.53 to 0.91 for acute respiratory illness) to be associated with better CLDSI score at the end of the study. Hospitalization was more frequent in patients with acute respiratory illness (p < 0.0001). Conclusions: Acute respiratory illness was associated with increased health-care utilization and obstruction to airflow, and worse functional status and well-being. At the end of the study, receipt of TC was associated with improvement and acute respiratory illness was associated with worsening in functional status and well-being.

Original languageEnglish (US)
Pages (from-to)1109-1116
Number of pages8
JournalChest
Volume130
Issue number4
DOIs
StatePublished - Oct 2006
Externally publishedYes

Fingerprint

Chronic Obstructive Pulmonary Disease
Human Influenza
Vaccination
Viruses
Lung Diseases
Chronic Disease
Influenza Vaccines
Odds Ratio
Patient Acceptance of Health Care
Inactivated Vaccines
Spirometry
Veterans
Virus Diseases
Orthomyxoviridae
Hospitalization
Logistic Models
Placebos

Keywords

  • COPD
  • Health-related quality of life
  • Influenza virus
  • Pulmonary function
  • Vaccine

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Gorse, G. J., O'Connor, T. Z., Young, S. L., Habib, M. P., Wittes, J., Neuzil, K. M., & Nichol, K. L. (2006). Impact of a winter respiratory virus season on patients with COPD and association with influenza vaccination. Chest, 130(4), 1109-1116. https://doi.org/10.1378/chest.130.4.1109

Impact of a winter respiratory virus season on patients with COPD and association with influenza vaccination. / Gorse, Geoffrey J.; O'Connor, Theresa Z.; Young, Stephen L.; Habib, Michael P; Wittes, Janet; Neuzil, Kathleen M.; Nichol, Kristin L.

In: Chest, Vol. 130, No. 4, 10.2006, p. 1109-1116.

Research output: Contribution to journalArticle

Gorse, GJ, O'Connor, TZ, Young, SL, Habib, MP, Wittes, J, Neuzil, KM & Nichol, KL 2006, 'Impact of a winter respiratory virus season on patients with COPD and association with influenza vaccination', Chest, vol. 130, no. 4, pp. 1109-1116. https://doi.org/10.1378/chest.130.4.1109
Gorse, Geoffrey J. ; O'Connor, Theresa Z. ; Young, Stephen L. ; Habib, Michael P ; Wittes, Janet ; Neuzil, Kathleen M. ; Nichol, Kristin L. / Impact of a winter respiratory virus season on patients with COPD and association with influenza vaccination. In: Chest. 2006 ; Vol. 130, No. 4. pp. 1109-1116.
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abstract = "Background: We assessed the effects of an influenza season on patients with COPD. Data from 2,215 veterans in a multicenter, randomized, double-blind influenza vaccine efficacy study were analyzed for changes in spirometric and functional status, comparing patients with laboratory-documented influenza (LDI)-caused illness, non-LDI-caused respiratory illness, or no illness, and for association with influenza vaccination. Methods: Patients received either IM trivalent inactivated influenza virus vaccine (TIV) plus intranasal trivalent, live attenuated, cold-adapted influenza virus vaccine (TC) or TIV plus intranasal placebo (TP). We performed spirometry, measured the chronic lung disease severity index (CLDSI) score to assess functional status and well-being, and tested for influenza virus infection. Results: Worsening in FEV 1, percentage of predicted FEV1, and CLDSI score (p < 0.001) was associated with acute respiratory illness in 585 illnesses including 94 LDI-caused illnesses. LDI-caused illness was more likely to be associated with worsening in FEV1 and CLDSI score acutely than non-LDI-caused illness (p < 0.01). Logistic regression showed acute respiratory illness (odds ratio [OR], 1.78; 95{\%} confidence limit [CL], 1.40 to 2.26) to be associated with worsening in CLDSI score, and receipt of TC (OR, 1.39; 95{\%} CL, 1.10 to 1.74) and no illness (OR, 0.70; 95{\%} CL, 0.53 to 0.91 for acute respiratory illness) to be associated with better CLDSI score at the end of the study. Hospitalization was more frequent in patients with acute respiratory illness (p < 0.0001). Conclusions: Acute respiratory illness was associated with increased health-care utilization and obstruction to airflow, and worse functional status and well-being. At the end of the study, receipt of TC was associated with improvement and acute respiratory illness was associated with worsening in functional status and well-being.",
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AU - O'Connor, Theresa Z.

AU - Young, Stephen L.

AU - Habib, Michael P

AU - Wittes, Janet

AU - Neuzil, Kathleen M.

AU - Nichol, Kristin L.

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N2 - Background: We assessed the effects of an influenza season on patients with COPD. Data from 2,215 veterans in a multicenter, randomized, double-blind influenza vaccine efficacy study were analyzed for changes in spirometric and functional status, comparing patients with laboratory-documented influenza (LDI)-caused illness, non-LDI-caused respiratory illness, or no illness, and for association with influenza vaccination. Methods: Patients received either IM trivalent inactivated influenza virus vaccine (TIV) plus intranasal trivalent, live attenuated, cold-adapted influenza virus vaccine (TC) or TIV plus intranasal placebo (TP). We performed spirometry, measured the chronic lung disease severity index (CLDSI) score to assess functional status and well-being, and tested for influenza virus infection. Results: Worsening in FEV 1, percentage of predicted FEV1, and CLDSI score (p < 0.001) was associated with acute respiratory illness in 585 illnesses including 94 LDI-caused illnesses. LDI-caused illness was more likely to be associated with worsening in FEV1 and CLDSI score acutely than non-LDI-caused illness (p < 0.01). Logistic regression showed acute respiratory illness (odds ratio [OR], 1.78; 95% confidence limit [CL], 1.40 to 2.26) to be associated with worsening in CLDSI score, and receipt of TC (OR, 1.39; 95% CL, 1.10 to 1.74) and no illness (OR, 0.70; 95% CL, 0.53 to 0.91 for acute respiratory illness) to be associated with better CLDSI score at the end of the study. Hospitalization was more frequent in patients with acute respiratory illness (p < 0.0001). Conclusions: Acute respiratory illness was associated with increased health-care utilization and obstruction to airflow, and worse functional status and well-being. At the end of the study, receipt of TC was associated with improvement and acute respiratory illness was associated with worsening in functional status and well-being.

AB - Background: We assessed the effects of an influenza season on patients with COPD. Data from 2,215 veterans in a multicenter, randomized, double-blind influenza vaccine efficacy study were analyzed for changes in spirometric and functional status, comparing patients with laboratory-documented influenza (LDI)-caused illness, non-LDI-caused respiratory illness, or no illness, and for association with influenza vaccination. Methods: Patients received either IM trivalent inactivated influenza virus vaccine (TIV) plus intranasal trivalent, live attenuated, cold-adapted influenza virus vaccine (TC) or TIV plus intranasal placebo (TP). We performed spirometry, measured the chronic lung disease severity index (CLDSI) score to assess functional status and well-being, and tested for influenza virus infection. Results: Worsening in FEV 1, percentage of predicted FEV1, and CLDSI score (p < 0.001) was associated with acute respiratory illness in 585 illnesses including 94 LDI-caused illnesses. LDI-caused illness was more likely to be associated with worsening in FEV1 and CLDSI score acutely than non-LDI-caused illness (p < 0.01). Logistic regression showed acute respiratory illness (odds ratio [OR], 1.78; 95% confidence limit [CL], 1.40 to 2.26) to be associated with worsening in CLDSI score, and receipt of TC (OR, 1.39; 95% CL, 1.10 to 1.74) and no illness (OR, 0.70; 95% CL, 0.53 to 0.91 for acute respiratory illness) to be associated with better CLDSI score at the end of the study. Hospitalization was more frequent in patients with acute respiratory illness (p < 0.0001). Conclusions: Acute respiratory illness was associated with increased health-care utilization and obstruction to airflow, and worse functional status and well-being. At the end of the study, receipt of TC was associated with improvement and acute respiratory illness was associated with worsening in functional status and well-being.

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KW - Health-related quality of life

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KW - Vaccine

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