Impact of CMV upon immune aging: facts and fiction

Mladen Jergović, Nico A. Contreras, Janko Nikolich-Zugich

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

Aging is accompanied by significant defects in immunity and compromised responses to new, previously unencountered microbial pathogens. Most humans carry several persistent or latent viruses as they age, interacting with the host immune systems for years. In that context maybe the most studied persistent virus is Cytomegalovirus, infamous for its ability to recruit very large T cell responses which increase with age and to simultaneously evade elimination by the immune system. Here we will address how lifelong CMV infection and the immunological burden of its control might affect immune reactivity and health of the host over time.

Original languageEnglish (US)
JournalMedical Microbiology and Immunology
DOIs
Publication statusPublished - Jan 1 2019

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Keywords

  • Aging
  • Cytomegalovirus
  • Latency
  • Memory inflation
  • T cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Microbiology (medical)

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