Impact of image-guided radiotherapy to reduce laryngeal edema following treatment for non-laryngeal and non-hypopharyngeal head and neck cancers

Nam P. Nguyen, Dave Abraham, Anand Desai, Michael Betz, Rick Davis, Thomas Sroka, Alexander Chi, Steven Gelumbauskas, Misty Ceizyk, Lexie Smith-Raymond, Michelle Stevie, Siyoung Jang, Russ Hamilton, Vincent Vinh-Hung

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

We would like to determine the effectiveness of image-guided radiotherapy (IGRT) to reduce laryngeal edema following treatment for head and neck cancer and to assess patient perception of voice and speech after treatment. We conducted a retrospective review of 44 patients undergoing radiation for non-laryngeal and non-hypopharyngeal head and neck cancers. Endoscopic and/or mirror examinations of the larynx were performed following radiotherapy at each follow-up visit. Laryngeal edema was assessed based on the Radiation Therapy Oncology Group grading scale. Patients were also asked to rate about the voice and speech quality relative to their pre-radiotherapy status. The mean laryngeal dose was 16.3 Gy (range: 11.7-45.5 Gy). At a median follow-up of 14 months (range: 2-31 months), three patients (7%) developed laryngeal edema (one grade 1, two grade 2). The mean laryngeal dose was respectively 20.3 Gy in two patients and 20.7 Gy in the third patient developing laryngeal edema. Except for one patient who continued to smoke and drink after radiotherapy, no patient reported any significant change in voice and speech quality after treatment. IGRT results in low rates and low severity of laryngeal edema following treatment for non-laryngeal and non-hypopharyngeal head and neck cancers and may preserve voice quality.

Original languageEnglish (US)
Pages (from-to)900-904
Number of pages5
JournalOral Oncology
Volume47
Issue number9
DOIs
StatePublished - Sep 2011

Keywords

  • Head and neck cancer
  • IGRT
  • Laryngeal edema
  • Voice preservation

ASJC Scopus subject areas

  • Oral Surgery
  • Oncology
  • Cancer Research

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    Nguyen, N. P., Abraham, D., Desai, A., Betz, M., Davis, R., Sroka, T., Chi, A., Gelumbauskas, S., Ceizyk, M., Smith-Raymond, L., Stevie, M., Jang, S., Hamilton, R., & Vinh-Hung, V. (2011). Impact of image-guided radiotherapy to reduce laryngeal edema following treatment for non-laryngeal and non-hypopharyngeal head and neck cancers. Oral Oncology, 47(9), 900-904. https://doi.org/10.1016/j.oraloncology.2011.06.004