Impact of physical activity on fatigue and quality of life in people with advanced lung cancer: A randomized controlled trial

H. M. Dhillon, Melanie L Bell, H. P. van der Ploeg, J. D. Turner, M. Kabourakis, L. Spencer, C. Lewis, R. Hui, P. Blinman, S. J. Clarke, M. J. Boyer, Janette L. Vardy

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Physical activity (PA) improves fatigue and quality of life (QOL) in cancer survivors. Our aim was to assess whether a 2-month PA intervention improves fatigue and QOL for people with advanced lung cancer. Methods: Participants with advanced lung cancer, Eastern Cooperative Oncology Group performance status (PS) ≤ 2, > 6 months life expectancy, and ability to complete six-min walk test, were stratified (disease stage, PS 0-1 versus 2, centre) and randomized (1:1) in an open-label study to usual care (UC) (nutrition and PA education materials) or experimental intervention (EX): UC plus 2-month supervised weekly PA and behaviour change sessions. Assessments occurred at baseline, 2, 4, and 6 months. The primary endpoint was fatigue [Functional Assessment of Cancer Therapy-Fatigue (FACT-F) questionnaire] at 2 months. The study was designed to detect a difference in mean FACT-F subscale score of 6. Analysis was intention-to-treat using linear mixed models. Results: We recruited 112 patients: 56 (50.4%) were randomized to EX, 55(49.5%) to UC; 1 ineligible. Male 55%; median age 64 years (34-80); 106 (96%) non-small cell lung cancer; 106 (95.5%) stage IV. At 2, 4 and 6 months, 90, 73 and 62 participants were assessed, respectively, with no difference in attrition between groups. There were no significant differences in fatigue between the groups at 2, 4 or 6 months: mean scores at 2 months EX 37.5, UC 36.4 (difference 1.2, 95% CI - 3.5, 5.8, P=0.62). There were no significant differences in QOL, symptoms, physical or functional status, or survival. Conclusions: Adherence to the intervention was good but the intervention group did not increase their PA enough compared to the control group, and no difference was seen in fatigue or QOL.

Original languageEnglish (US)
Article numbermdx205
Pages (from-to)1889-1897
Number of pages9
JournalAnnals of Oncology
Volume28
Issue number8
DOIs
StatePublished - Aug 1 2017

Fingerprint

Fatigue
Lung Neoplasms
Randomized Controlled Trials
Quality of Life
Exercise
Neoplasms
Intention to Treat Analysis
Physical Education and Training
Life Expectancy
Non-Small Cell Lung Carcinoma
Survivors
Linear Models
Control Groups
Survival
Therapeutics

Keywords

  • Fatigue
  • Lung cancer
  • Physical activity
  • Quality of life

ASJC Scopus subject areas

  • Hematology
  • Oncology

Cite this

Dhillon, H. M., Bell, M. L., van der Ploeg, H. P., Turner, J. D., Kabourakis, M., Spencer, L., ... Vardy, J. L. (2017). Impact of physical activity on fatigue and quality of life in people with advanced lung cancer: A randomized controlled trial. Annals of Oncology, 28(8), 1889-1897. [mdx205]. https://doi.org/10.1093/annonc/mdx205

Impact of physical activity on fatigue and quality of life in people with advanced lung cancer : A randomized controlled trial. / Dhillon, H. M.; Bell, Melanie L; van der Ploeg, H. P.; Turner, J. D.; Kabourakis, M.; Spencer, L.; Lewis, C.; Hui, R.; Blinman, P.; Clarke, S. J.; Boyer, M. J.; Vardy, Janette L.

In: Annals of Oncology, Vol. 28, No. 8, mdx205, 01.08.2017, p. 1889-1897.

Research output: Contribution to journalArticle

Dhillon, HM, Bell, ML, van der Ploeg, HP, Turner, JD, Kabourakis, M, Spencer, L, Lewis, C, Hui, R, Blinman, P, Clarke, SJ, Boyer, MJ & Vardy, JL 2017, 'Impact of physical activity on fatigue and quality of life in people with advanced lung cancer: A randomized controlled trial', Annals of Oncology, vol. 28, no. 8, mdx205, pp. 1889-1897. https://doi.org/10.1093/annonc/mdx205
Dhillon, H. M. ; Bell, Melanie L ; van der Ploeg, H. P. ; Turner, J. D. ; Kabourakis, M. ; Spencer, L. ; Lewis, C. ; Hui, R. ; Blinman, P. ; Clarke, S. J. ; Boyer, M. J. ; Vardy, Janette L. / Impact of physical activity on fatigue and quality of life in people with advanced lung cancer : A randomized controlled trial. In: Annals of Oncology. 2017 ; Vol. 28, No. 8. pp. 1889-1897.
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abstract = "Background: Physical activity (PA) improves fatigue and quality of life (QOL) in cancer survivors. Our aim was to assess whether a 2-month PA intervention improves fatigue and QOL for people with advanced lung cancer. Methods: Participants with advanced lung cancer, Eastern Cooperative Oncology Group performance status (PS) ≤ 2, > 6 months life expectancy, and ability to complete six-min walk test, were stratified (disease stage, PS 0-1 versus 2, centre) and randomized (1:1) in an open-label study to usual care (UC) (nutrition and PA education materials) or experimental intervention (EX): UC plus 2-month supervised weekly PA and behaviour change sessions. Assessments occurred at baseline, 2, 4, and 6 months. The primary endpoint was fatigue [Functional Assessment of Cancer Therapy-Fatigue (FACT-F) questionnaire] at 2 months. The study was designed to detect a difference in mean FACT-F subscale score of 6. Analysis was intention-to-treat using linear mixed models. Results: We recruited 112 patients: 56 (50.4{\%}) were randomized to EX, 55(49.5{\%}) to UC; 1 ineligible. Male 55{\%}; median age 64 years (34-80); 106 (96{\%}) non-small cell lung cancer; 106 (95.5{\%}) stage IV. At 2, 4 and 6 months, 90, 73 and 62 participants were assessed, respectively, with no difference in attrition between groups. There were no significant differences in fatigue between the groups at 2, 4 or 6 months: mean scores at 2 months EX 37.5, UC 36.4 (difference 1.2, 95{\%} CI - 3.5, 5.8, P=0.62). There were no significant differences in QOL, symptoms, physical or functional status, or survival. Conclusions: Adherence to the intervention was good but the intervention group did not increase their PA enough compared to the control group, and no difference was seen in fatigue or QOL.",
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AU - Turner, J. D.

AU - Kabourakis, M.

AU - Spencer, L.

AU - Lewis, C.

AU - Hui, R.

AU - Blinman, P.

AU - Clarke, S. J.

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