Impact of sex on long-term clinical outcomes after percutaneous coronary intervention

Seyed Mohammad Ghoreyshi-Hefzabad, Seyed Ebrahim Kassaian, Shahrbanoo Kheirkhah-Sabetghadam, Arash Jalali, Hamidreza Poorhosseini, Mohammad R Movahed, Ebrahim Nematipour, Mojtaba Salarifar, Mohammad Alidoosti, Seyedeharezoo Ghoreyshi-Hefzabad, Farshid Alaeddini, Saeed Sadeghian, Masoumeh Lotfi-Tokaldany

Research output: Contribution to journalArticle

Abstract

Aims: To evaluate the impact of sex on long-term clinical outcomes after percutaneous coronary intervention (PCI). Methods: In a large prospective cohort, 5664 patients (1716 women and 3948 men) who underwent PCI in a tertiary cardiac center between March 2007 and March 2010 were enrolled. Patients were followed up for median of 74.3 months. We compared the occurrence of long-term mortality, myocardial infarction (MI), and repeated revascularization between 2 sexes. Major adverse cardiac events were defined as a composite end point consisting of occurrence of all-cause mortality, nonfatal MI, or target vessel revascularization during follow-up period. Results: Women were older and had more conventional coronary artery disease risk factors, had smaller vessel diameter, and received drug-eluting stents more frequently than men. On the contrary, men were much more smokers and had higher frequency of acute coronary syndrome, multivessel disease, total coronary occlusion, and lower ejection fraction. After >6 years of follow-up, the all-cause mortality, nonfatal MI, target vessel revascularization, major adverse cardiac events, patient-oriented composite end point, and total repeat PCI were similar between 2 sexes. After adjusting for potential confounders, the total repeat PCI was the only observed difference that was significantly lower in women [11.2% in women vs. 12.4% in men, adjusted subdistributional hazard ratio=0.73 (95% confidence interval, 0.6-0.88); P = 0.001). Conclusions: During >6 years of follow-up, no significant difference was observed in major clinical outcomes between 2 sexes.

Original languageEnglish (US)
Pages (from-to)161-166
Number of pages6
JournalCritical Pathways in Cardiology
Volume16
Issue number4
DOIs
StatePublished - Jan 1 2017

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Percutaneous Coronary Intervention
Myocardial Infarction
Mortality
Drug-Eluting Stents
Coronary Occlusion
Acute Coronary Syndrome
Coronary Artery Disease
Confidence Intervals

Keywords

  • Mortality
  • Percutaneous coronary intervention
  • Sex

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Ghoreyshi-Hefzabad, S. M., Kassaian, S. E., Kheirkhah-Sabetghadam, S., Jalali, A., Poorhosseini, H., Movahed, M. R., ... Lotfi-Tokaldany, M. (2017). Impact of sex on long-term clinical outcomes after percutaneous coronary intervention. Critical Pathways in Cardiology, 16(4), 161-166. https://doi.org/10.1097/HPC.0000000000000126

Impact of sex on long-term clinical outcomes after percutaneous coronary intervention. / Ghoreyshi-Hefzabad, Seyed Mohammad; Kassaian, Seyed Ebrahim; Kheirkhah-Sabetghadam, Shahrbanoo; Jalali, Arash; Poorhosseini, Hamidreza; Movahed, Mohammad R; Nematipour, Ebrahim; Salarifar, Mojtaba; Alidoosti, Mohammad; Ghoreyshi-Hefzabad, Seyedeharezoo; Alaeddini, Farshid; Sadeghian, Saeed; Lotfi-Tokaldany, Masoumeh.

In: Critical Pathways in Cardiology, Vol. 16, No. 4, 01.01.2017, p. 161-166.

Research output: Contribution to journalArticle

Ghoreyshi-Hefzabad, SM, Kassaian, SE, Kheirkhah-Sabetghadam, S, Jalali, A, Poorhosseini, H, Movahed, MR, Nematipour, E, Salarifar, M, Alidoosti, M, Ghoreyshi-Hefzabad, S, Alaeddini, F, Sadeghian, S & Lotfi-Tokaldany, M 2017, 'Impact of sex on long-term clinical outcomes after percutaneous coronary intervention', Critical Pathways in Cardiology, vol. 16, no. 4, pp. 161-166. https://doi.org/10.1097/HPC.0000000000000126
Ghoreyshi-Hefzabad SM, Kassaian SE, Kheirkhah-Sabetghadam S, Jalali A, Poorhosseini H, Movahed MR et al. Impact of sex on long-term clinical outcomes after percutaneous coronary intervention. Critical Pathways in Cardiology. 2017 Jan 1;16(4):161-166. https://doi.org/10.1097/HPC.0000000000000126
Ghoreyshi-Hefzabad, Seyed Mohammad ; Kassaian, Seyed Ebrahim ; Kheirkhah-Sabetghadam, Shahrbanoo ; Jalali, Arash ; Poorhosseini, Hamidreza ; Movahed, Mohammad R ; Nematipour, Ebrahim ; Salarifar, Mojtaba ; Alidoosti, Mohammad ; Ghoreyshi-Hefzabad, Seyedeharezoo ; Alaeddini, Farshid ; Sadeghian, Saeed ; Lotfi-Tokaldany, Masoumeh. / Impact of sex on long-term clinical outcomes after percutaneous coronary intervention. In: Critical Pathways in Cardiology. 2017 ; Vol. 16, No. 4. pp. 161-166.
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AU - Ghoreyshi-Hefzabad, Seyed Mohammad

AU - Kassaian, Seyed Ebrahim

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AU - Jalali, Arash

AU - Poorhosseini, Hamidreza

AU - Movahed, Mohammad R

AU - Nematipour, Ebrahim

AU - Salarifar, Mojtaba

AU - Alidoosti, Mohammad

AU - Ghoreyshi-Hefzabad, Seyedeharezoo

AU - Alaeddini, Farshid

AU - Sadeghian, Saeed

AU - Lotfi-Tokaldany, Masoumeh

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N2 - Aims: To evaluate the impact of sex on long-term clinical outcomes after percutaneous coronary intervention (PCI). Methods: In a large prospective cohort, 5664 patients (1716 women and 3948 men) who underwent PCI in a tertiary cardiac center between March 2007 and March 2010 were enrolled. Patients were followed up for median of 74.3 months. We compared the occurrence of long-term mortality, myocardial infarction (MI), and repeated revascularization between 2 sexes. Major adverse cardiac events were defined as a composite end point consisting of occurrence of all-cause mortality, nonfatal MI, or target vessel revascularization during follow-up period. Results: Women were older and had more conventional coronary artery disease risk factors, had smaller vessel diameter, and received drug-eluting stents more frequently than men. On the contrary, men were much more smokers and had higher frequency of acute coronary syndrome, multivessel disease, total coronary occlusion, and lower ejection fraction. After >6 years of follow-up, the all-cause mortality, nonfatal MI, target vessel revascularization, major adverse cardiac events, patient-oriented composite end point, and total repeat PCI were similar between 2 sexes. After adjusting for potential confounders, the total repeat PCI was the only observed difference that was significantly lower in women [11.2% in women vs. 12.4% in men, adjusted subdistributional hazard ratio=0.73 (95% confidence interval, 0.6-0.88); P = 0.001). Conclusions: During >6 years of follow-up, no significant difference was observed in major clinical outcomes between 2 sexes.

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KW - Mortality

KW - Percutaneous coronary intervention

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