Impact of thermal stress on placental function and fetal physiology

Sean W Limesand, Leticia E. Camacho, Amy C. Kelly, Andrew T. Antolic

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In ruminants, prolonged exposure to high ambient temperatures negatively affects placental development and function. The pursuing limitations in placental oxygen and nutrient supply between the mother and fetus slow fetal growth lowering birth weights and postnatal performance. The pregnant ewe is a long-standing animal model for the study of maternal-fetal interactions and is susceptible to naturally occurring heat stress, which causes fetal growth restriction. In the pregnant ewe, studies show that the fetus adapts to hyperthermia-induced placental insufficiency to preserve placental transport capacity of oxygen and nutrients. These adaptive responses are at the expense of normal fetal development and growth. Enlarged transplacental gradient for oxygen and glucose facilitates diffusion across the placenta, but develops by lowering fetal blood oxygen and glucose concentrations. Fetal hypoxemia and hypoglycemia slow growth and alter their metabolic and endocrine profiles. Deficits in amino acids transport across the placenta are present but are overcome by reduced fetal clearance rates, likely due to fetal hypoxemia or endocrine responses to hypoxic stress. Here, we provide an overview of the performance limitations observed in ruminants exposed to heat stress during pregnancy, but we focus our presentation on the sheep fetus in pregnancies complicated by hyperthermia-induced placental insufficiency. We define the characteristics of placental dysfunction observed in the fetus of heat stressed ewes during pregnancy and present developmental adaptations in organogenesis, metabolism, and endocrinology that are proposed to establish maladaptive situations reaching far beyond the perinatal period.

Original languageEnglish (US)
Pages (from-to)886-898
Number of pages13
JournalAnimal Reproduction
Volume15
DOIs
StatePublished - Jan 1 2018

Fingerprint

thermal stress
fetal development
Fetal Development
fetus
Fetus
physiology
Hot Temperature
Placental Insufficiency
Oxygen
oxygen
ewes
Induced Hyperthermia
Ruminants
pregnancy
placenta
Pregnancy
Placenta
fever
heat stress
hypoxia

Keywords

  • Heat stress
  • Intrauterine growth restriction
  • Placental insufficiency
  • Sheep fetus

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Impact of thermal stress on placental function and fetal physiology. / Limesand, Sean W; Camacho, Leticia E.; Kelly, Amy C.; Antolic, Andrew T.

In: Animal Reproduction, Vol. 15, 01.01.2018, p. 886-898.

Research output: Contribution to journalArticle

Limesand, Sean W ; Camacho, Leticia E. ; Kelly, Amy C. ; Antolic, Andrew T. / Impact of thermal stress on placental function and fetal physiology. In: Animal Reproduction. 2018 ; Vol. 15. pp. 886-898.
@article{db041be2be13415494b1eed9a2a1f789,
title = "Impact of thermal stress on placental function and fetal physiology",
abstract = "In ruminants, prolonged exposure to high ambient temperatures negatively affects placental development and function. The pursuing limitations in placental oxygen and nutrient supply between the mother and fetus slow fetal growth lowering birth weights and postnatal performance. The pregnant ewe is a long-standing animal model for the study of maternal-fetal interactions and is susceptible to naturally occurring heat stress, which causes fetal growth restriction. In the pregnant ewe, studies show that the fetus adapts to hyperthermia-induced placental insufficiency to preserve placental transport capacity of oxygen and nutrients. These adaptive responses are at the expense of normal fetal development and growth. Enlarged transplacental gradient for oxygen and glucose facilitates diffusion across the placenta, but develops by lowering fetal blood oxygen and glucose concentrations. Fetal hypoxemia and hypoglycemia slow growth and alter their metabolic and endocrine profiles. Deficits in amino acids transport across the placenta are present but are overcome by reduced fetal clearance rates, likely due to fetal hypoxemia or endocrine responses to hypoxic stress. Here, we provide an overview of the performance limitations observed in ruminants exposed to heat stress during pregnancy, but we focus our presentation on the sheep fetus in pregnancies complicated by hyperthermia-induced placental insufficiency. We define the characteristics of placental dysfunction observed in the fetus of heat stressed ewes during pregnancy and present developmental adaptations in organogenesis, metabolism, and endocrinology that are proposed to establish maladaptive situations reaching far beyond the perinatal period.",
keywords = "Heat stress, Intrauterine growth restriction, Placental insufficiency, Sheep fetus",
author = "Limesand, {Sean W} and Camacho, {Leticia E.} and Kelly, {Amy C.} and Antolic, {Andrew T.}",
year = "2018",
month = "1",
day = "1",
doi = "10.21451/1984-3143-AR2018-0056",
language = "English (US)",
volume = "15",
pages = "886--898",
journal = "Animal Reproduction",
issn = "1806-9614",
publisher = "Colegio Brasileiro de Reproducao Animal",

}

TY - JOUR

T1 - Impact of thermal stress on placental function and fetal physiology

AU - Limesand, Sean W

AU - Camacho, Leticia E.

AU - Kelly, Amy C.

AU - Antolic, Andrew T.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - In ruminants, prolonged exposure to high ambient temperatures negatively affects placental development and function. The pursuing limitations in placental oxygen and nutrient supply between the mother and fetus slow fetal growth lowering birth weights and postnatal performance. The pregnant ewe is a long-standing animal model for the study of maternal-fetal interactions and is susceptible to naturally occurring heat stress, which causes fetal growth restriction. In the pregnant ewe, studies show that the fetus adapts to hyperthermia-induced placental insufficiency to preserve placental transport capacity of oxygen and nutrients. These adaptive responses are at the expense of normal fetal development and growth. Enlarged transplacental gradient for oxygen and glucose facilitates diffusion across the placenta, but develops by lowering fetal blood oxygen and glucose concentrations. Fetal hypoxemia and hypoglycemia slow growth and alter their metabolic and endocrine profiles. Deficits in amino acids transport across the placenta are present but are overcome by reduced fetal clearance rates, likely due to fetal hypoxemia or endocrine responses to hypoxic stress. Here, we provide an overview of the performance limitations observed in ruminants exposed to heat stress during pregnancy, but we focus our presentation on the sheep fetus in pregnancies complicated by hyperthermia-induced placental insufficiency. We define the characteristics of placental dysfunction observed in the fetus of heat stressed ewes during pregnancy and present developmental adaptations in organogenesis, metabolism, and endocrinology that are proposed to establish maladaptive situations reaching far beyond the perinatal period.

AB - In ruminants, prolonged exposure to high ambient temperatures negatively affects placental development and function. The pursuing limitations in placental oxygen and nutrient supply between the mother and fetus slow fetal growth lowering birth weights and postnatal performance. The pregnant ewe is a long-standing animal model for the study of maternal-fetal interactions and is susceptible to naturally occurring heat stress, which causes fetal growth restriction. In the pregnant ewe, studies show that the fetus adapts to hyperthermia-induced placental insufficiency to preserve placental transport capacity of oxygen and nutrients. These adaptive responses are at the expense of normal fetal development and growth. Enlarged transplacental gradient for oxygen and glucose facilitates diffusion across the placenta, but develops by lowering fetal blood oxygen and glucose concentrations. Fetal hypoxemia and hypoglycemia slow growth and alter their metabolic and endocrine profiles. Deficits in amino acids transport across the placenta are present but are overcome by reduced fetal clearance rates, likely due to fetal hypoxemia or endocrine responses to hypoxic stress. Here, we provide an overview of the performance limitations observed in ruminants exposed to heat stress during pregnancy, but we focus our presentation on the sheep fetus in pregnancies complicated by hyperthermia-induced placental insufficiency. We define the characteristics of placental dysfunction observed in the fetus of heat stressed ewes during pregnancy and present developmental adaptations in organogenesis, metabolism, and endocrinology that are proposed to establish maladaptive situations reaching far beyond the perinatal period.

KW - Heat stress

KW - Intrauterine growth restriction

KW - Placental insufficiency

KW - Sheep fetus

UR - http://www.scopus.com/inward/record.url?scp=85062015125&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85062015125&partnerID=8YFLogxK

U2 - 10.21451/1984-3143-AR2018-0056

DO - 10.21451/1984-3143-AR2018-0056

M3 - Article

AN - SCOPUS:85062015125

VL - 15

SP - 886

EP - 898

JO - Animal Reproduction

JF - Animal Reproduction

SN - 1806-9614

ER -