Impact of treating facilities' volume on survival for early-stage laryngeal cancer

Amy Y. Chen, Alex Pavluck, Michael Halpern, Elizabeth Ward

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Background. Treatment at a high-volume facility has been associated with better outcomes in a variety of conditions. The relationship between volume and survival from laryngeal cancer has not been examined previously. Methods. A total of 11,446 early-stage laryngeal cancer patients (1996-1998) who reported to the National Cancer Database (NCDB) were analyzed. Proportional hazards regression was used to assess the relationship between survival and treatment volume controlling for other factors associated with survival. Results. Treatment at low-volume facilities was associated with a significantly increased likelihood of death (hazard ratio 1.20, 95% CI 1.04-1.38). Surgical resection, as compared with radiation treatment, was associated with lower mortality (HR 0.74, 95% CI 0.69-0.80). Conclusion. This study is the first to assess the relationship between survival and treatment volume in laryngeal cancer. Treatment at a high-volume facility is associated with better survival. Surgical treatment rather than radiation was also associated with better survival, although we could not control for confounders that may bias treatment selection.

Original languageEnglish (US)
Pages (from-to)1137-1143
Number of pages7
JournalHead and Neck
Volume31
Issue number9
DOIs
StatePublished - Sep 2009
Externally publishedYes

Fingerprint

Laryngeal Neoplasms
Survival
Therapeutics
Radiation
Selection Bias
Databases
Mortality

Keywords

  • Disparities
  • Laryngeal cancer
  • Quality of care
  • Radiation
  • Surgery

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Impact of treating facilities' volume on survival for early-stage laryngeal cancer. / Chen, Amy Y.; Pavluck, Alex; Halpern, Michael; Ward, Elizabeth.

In: Head and Neck, Vol. 31, No. 9, 09.2009, p. 1137-1143.

Research output: Contribution to journalArticle

Chen, Amy Y. ; Pavluck, Alex ; Halpern, Michael ; Ward, Elizabeth. / Impact of treating facilities' volume on survival for early-stage laryngeal cancer. In: Head and Neck. 2009 ; Vol. 31, No. 9. pp. 1137-1143.
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