Impact of treatment with continuous positive airway pressure (CPAP) on weight in obstructive sleep apnea

Stuart F Quan, Rohit Budhiraja, Denise P. Clarke, James L. Goodwin, Daniel J. Gottlieb, Deborah A. Nichols, Richard D. Simon, Terry W. Smith, James K. Walsh, Clete A. Kushida

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Study Objective: To determine the impact of continuous positive airway pressure (CPAP) on weight change in persons with obstructive sleep apnea (OSA). Design, Setting, and Participants: The Apnea Positive Pressure Long-term Efficacy Study (APPLES) was a 6-month, randomized, double-blinded sham-controlled multicenter clinical trial conducted at 5 sites in the United States. Of 1,105 participants with an apnea hypopnea index ≥ 10 events/hour initially randomized, 812 had body weight measured at baseline and after 6 months of study. Intervention: CPAP or Sham CPAP. measurements: Body weight, height, hours of CPAP or Sham CPAP use, Epworth Sleepiness Scale score. Results: Participants randomized to CPAP gained 0.35 ± 5.01 kg, whereas those on Sham CPAP lost 0.70 ± 4.03 kg (mean ± SD, p = 0.001). Amount of weight gain with CPAP was related to hours of device adherence, with each hour per night of use predicting a 0.42 kg increase in weight. This association was not noted in the Sham CPAP group. CPAP participants who used their device ≥ 4 h per night on ≥ 70% of nights gained the most weight over 6 months in comparison to non-adherent CPAP participants (1.0 ± 5.3 vs. -0.3 ± 5.0 kg, p = 0.014). Conclusions: OSA patients using CPAP may gain a modest amount of weight with the greatest weight gain found in those most compliant with CPAP.

Original languageEnglish (US)
Pages (from-to)989-993
Number of pages5
JournalJournal of Clinical Sleep Medicine
Volume9
Issue number10
DOIs
StatePublished - 2013

Fingerprint

Continuous Positive Airway Pressure
Obstructive Sleep Apnea
Weights and Measures
Therapeutics
Apnea
Weight Gain
Body Weight
Equipment and Supplies
Body Height
Controlled Clinical Trials
Multicenter Studies

Keywords

  • Continuous positive airway pressure
  • Obstructive sleep apnea
  • Weight

ASJC Scopus subject areas

  • Clinical Neurology
  • Pulmonary and Respiratory Medicine
  • Neurology

Cite this

Quan, S. F., Budhiraja, R., Clarke, D. P., Goodwin, J. L., Gottlieb, D. J., Nichols, D. A., ... Kushida, C. A. (2013). Impact of treatment with continuous positive airway pressure (CPAP) on weight in obstructive sleep apnea. Journal of Clinical Sleep Medicine, 9(10), 989-993. https://doi.org/10.5664/jcsm.3064

Impact of treatment with continuous positive airway pressure (CPAP) on weight in obstructive sleep apnea. / Quan, Stuart F; Budhiraja, Rohit; Clarke, Denise P.; Goodwin, James L.; Gottlieb, Daniel J.; Nichols, Deborah A.; Simon, Richard D.; Smith, Terry W.; Walsh, James K.; Kushida, Clete A.

In: Journal of Clinical Sleep Medicine, Vol. 9, No. 10, 2013, p. 989-993.

Research output: Contribution to journalArticle

Quan, SF, Budhiraja, R, Clarke, DP, Goodwin, JL, Gottlieb, DJ, Nichols, DA, Simon, RD, Smith, TW, Walsh, JK & Kushida, CA 2013, 'Impact of treatment with continuous positive airway pressure (CPAP) on weight in obstructive sleep apnea', Journal of Clinical Sleep Medicine, vol. 9, no. 10, pp. 989-993. https://doi.org/10.5664/jcsm.3064
Quan, Stuart F ; Budhiraja, Rohit ; Clarke, Denise P. ; Goodwin, James L. ; Gottlieb, Daniel J. ; Nichols, Deborah A. ; Simon, Richard D. ; Smith, Terry W. ; Walsh, James K. ; Kushida, Clete A. / Impact of treatment with continuous positive airway pressure (CPAP) on weight in obstructive sleep apnea. In: Journal of Clinical Sleep Medicine. 2013 ; Vol. 9, No. 10. pp. 989-993.
@article{4177b637f2ae406c983afa079cef7927,
title = "Impact of treatment with continuous positive airway pressure (CPAP) on weight in obstructive sleep apnea",
abstract = "Study Objective: To determine the impact of continuous positive airway pressure (CPAP) on weight change in persons with obstructive sleep apnea (OSA). Design, Setting, and Participants: The Apnea Positive Pressure Long-term Efficacy Study (APPLES) was a 6-month, randomized, double-blinded sham-controlled multicenter clinical trial conducted at 5 sites in the United States. Of 1,105 participants with an apnea hypopnea index ≥ 10 events/hour initially randomized, 812 had body weight measured at baseline and after 6 months of study. Intervention: CPAP or Sham CPAP. measurements: Body weight, height, hours of CPAP or Sham CPAP use, Epworth Sleepiness Scale score. Results: Participants randomized to CPAP gained 0.35 ± 5.01 kg, whereas those on Sham CPAP lost 0.70 ± 4.03 kg (mean ± SD, p = 0.001). Amount of weight gain with CPAP was related to hours of device adherence, with each hour per night of use predicting a 0.42 kg increase in weight. This association was not noted in the Sham CPAP group. CPAP participants who used their device ≥ 4 h per night on ≥ 70{\%} of nights gained the most weight over 6 months in comparison to non-adherent CPAP participants (1.0 ± 5.3 vs. -0.3 ± 5.0 kg, p = 0.014). Conclusions: OSA patients using CPAP may gain a modest amount of weight with the greatest weight gain found in those most compliant with CPAP.",
keywords = "Continuous positive airway pressure, Obstructive sleep apnea, Weight",
author = "Quan, {Stuart F} and Rohit Budhiraja and Clarke, {Denise P.} and Goodwin, {James L.} and Gottlieb, {Daniel J.} and Nichols, {Deborah A.} and Simon, {Richard D.} and Smith, {Terry W.} and Walsh, {James K.} and Kushida, {Clete A.}",
year = "2013",
doi = "10.5664/jcsm.3064",
language = "English (US)",
volume = "9",
pages = "989--993",
journal = "Journal of Clinical Sleep Medicine",
issn = "1550-9389",
publisher = "American Academy of Sleep Medicine",
number = "10",

}

TY - JOUR

T1 - Impact of treatment with continuous positive airway pressure (CPAP) on weight in obstructive sleep apnea

AU - Quan, Stuart F

AU - Budhiraja, Rohit

AU - Clarke, Denise P.

AU - Goodwin, James L.

AU - Gottlieb, Daniel J.

AU - Nichols, Deborah A.

AU - Simon, Richard D.

AU - Smith, Terry W.

AU - Walsh, James K.

AU - Kushida, Clete A.

PY - 2013

Y1 - 2013

N2 - Study Objective: To determine the impact of continuous positive airway pressure (CPAP) on weight change in persons with obstructive sleep apnea (OSA). Design, Setting, and Participants: The Apnea Positive Pressure Long-term Efficacy Study (APPLES) was a 6-month, randomized, double-blinded sham-controlled multicenter clinical trial conducted at 5 sites in the United States. Of 1,105 participants with an apnea hypopnea index ≥ 10 events/hour initially randomized, 812 had body weight measured at baseline and after 6 months of study. Intervention: CPAP or Sham CPAP. measurements: Body weight, height, hours of CPAP or Sham CPAP use, Epworth Sleepiness Scale score. Results: Participants randomized to CPAP gained 0.35 ± 5.01 kg, whereas those on Sham CPAP lost 0.70 ± 4.03 kg (mean ± SD, p = 0.001). Amount of weight gain with CPAP was related to hours of device adherence, with each hour per night of use predicting a 0.42 kg increase in weight. This association was not noted in the Sham CPAP group. CPAP participants who used their device ≥ 4 h per night on ≥ 70% of nights gained the most weight over 6 months in comparison to non-adherent CPAP participants (1.0 ± 5.3 vs. -0.3 ± 5.0 kg, p = 0.014). Conclusions: OSA patients using CPAP may gain a modest amount of weight with the greatest weight gain found in those most compliant with CPAP.

AB - Study Objective: To determine the impact of continuous positive airway pressure (CPAP) on weight change in persons with obstructive sleep apnea (OSA). Design, Setting, and Participants: The Apnea Positive Pressure Long-term Efficacy Study (APPLES) was a 6-month, randomized, double-blinded sham-controlled multicenter clinical trial conducted at 5 sites in the United States. Of 1,105 participants with an apnea hypopnea index ≥ 10 events/hour initially randomized, 812 had body weight measured at baseline and after 6 months of study. Intervention: CPAP or Sham CPAP. measurements: Body weight, height, hours of CPAP or Sham CPAP use, Epworth Sleepiness Scale score. Results: Participants randomized to CPAP gained 0.35 ± 5.01 kg, whereas those on Sham CPAP lost 0.70 ± 4.03 kg (mean ± SD, p = 0.001). Amount of weight gain with CPAP was related to hours of device adherence, with each hour per night of use predicting a 0.42 kg increase in weight. This association was not noted in the Sham CPAP group. CPAP participants who used their device ≥ 4 h per night on ≥ 70% of nights gained the most weight over 6 months in comparison to non-adherent CPAP participants (1.0 ± 5.3 vs. -0.3 ± 5.0 kg, p = 0.014). Conclusions: OSA patients using CPAP may gain a modest amount of weight with the greatest weight gain found in those most compliant with CPAP.

KW - Continuous positive airway pressure

KW - Obstructive sleep apnea

KW - Weight

UR - http://www.scopus.com/inward/record.url?scp=84888193691&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84888193691&partnerID=8YFLogxK

U2 - 10.5664/jcsm.3064

DO - 10.5664/jcsm.3064

M3 - Article

C2 - 24127141

AN - SCOPUS:84888193691

VL - 9

SP - 989

EP - 993

JO - Journal of Clinical Sleep Medicine

JF - Journal of Clinical Sleep Medicine

SN - 1550-9389

IS - 10

ER -