Impact of tumor board recommendations on treatment outcome for locally advanced head and neck cancer

Nam P. Nguyen, Paul Vos, Howard Lee, Thomas L. Borok, Ulf Karlsson, Tomas Martinez, James Welsh, Deirdre Cohen, Russell J Hamilton, Nga Nguyen, Ly M. Nguyen, Vincent Vinh-Hung

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background/Aims: To identify physician selection factors in the treatment of locally advanced head and neck cancer and how treatment outcome is affected by Tumor Board recommendations. Methods: A retrospective analysis of 213 patients treated for locally advanced head and neck cancer in a single institution was performed. All treatments followed Tumor Board recommendations: 115 patients had chemotherapy and radiation, and 98 patients received postoperative radiation. Patient characteristics, treatment toxicity, locoregional control and survival between these two treat- ment groups were compared. Patient survival was compared with survival data reported in randomized studies of locally advanced head and neck cancer. Results: There were no differences in comorbidity factors, and T or N stages between the two groups. A statistically significant number of patients with oropharyngeal and oral cavity tumors had chemoradiation and postoperative radiation, respectively (p < 0.0001). Grade 3-4 toxicities during treatment were 48 and 87% for the postoperative radiation and chemoradiation groups, respectively (p = 0.0001). There were no differences in survival, locoregional recurrences and distant metastases between the two groups. Patient survival was comparable to survival rates reported by randomized studies of locally advanced head and neck cancer. Conclusion: Disease sites remained the key determining factor for treatment selection. Multidisciplinary approaches provided optimal treatment outcome for locally advanced head and neck cancer, with overall survival in these patients being comparable to that reported in randomized clinical trials.

Original languageEnglish (US)
Pages (from-to)186-191
Number of pages6
JournalOncology
Volume75
Issue number3-4
DOIs
StatePublished - Oct 2008

Fingerprint

Head and Neck Neoplasms
Survival
Neoplasms
Radiation
Therapeutics
Mouth
Comorbidity
Survival Rate
Randomized Controlled Trials
Neoplasm Metastasis
Physicians
Recurrence
Drug Therapy

Keywords

  • Chemoradiation
  • Head and neck cancer
  • Postoperative radiation
  • Treatment selection
  • Tumor Board recommendations

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Nguyen, N. P., Vos, P., Lee, H., Borok, T. L., Karlsson, U., Martinez, T., ... Vinh-Hung, V. (2008). Impact of tumor board recommendations on treatment outcome for locally advanced head and neck cancer. Oncology, 75(3-4), 186-191. https://doi.org/10.1159/000163058

Impact of tumor board recommendations on treatment outcome for locally advanced head and neck cancer. / Nguyen, Nam P.; Vos, Paul; Lee, Howard; Borok, Thomas L.; Karlsson, Ulf; Martinez, Tomas; Welsh, James; Cohen, Deirdre; Hamilton, Russell J; Nguyen, Nga; Nguyen, Ly M.; Vinh-Hung, Vincent.

In: Oncology, Vol. 75, No. 3-4, 10.2008, p. 186-191.

Research output: Contribution to journalArticle

Nguyen, NP, Vos, P, Lee, H, Borok, TL, Karlsson, U, Martinez, T, Welsh, J, Cohen, D, Hamilton, RJ, Nguyen, N, Nguyen, LM & Vinh-Hung, V 2008, 'Impact of tumor board recommendations on treatment outcome for locally advanced head and neck cancer', Oncology, vol. 75, no. 3-4, pp. 186-191. https://doi.org/10.1159/000163058
Nguyen NP, Vos P, Lee H, Borok TL, Karlsson U, Martinez T et al. Impact of tumor board recommendations on treatment outcome for locally advanced head and neck cancer. Oncology. 2008 Oct;75(3-4):186-191. https://doi.org/10.1159/000163058
Nguyen, Nam P. ; Vos, Paul ; Lee, Howard ; Borok, Thomas L. ; Karlsson, Ulf ; Martinez, Tomas ; Welsh, James ; Cohen, Deirdre ; Hamilton, Russell J ; Nguyen, Nga ; Nguyen, Ly M. ; Vinh-Hung, Vincent. / Impact of tumor board recommendations on treatment outcome for locally advanced head and neck cancer. In: Oncology. 2008 ; Vol. 75, No. 3-4. pp. 186-191.
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