Impact of weight loss on serum leptin in obese postmenopausal women

Zaida R. Cordero-MacIntyre, Shiva Metghalchi, Jason Rosen, Warren Peters, Timothy G Lohman, Maria Luz Fernandez

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A 6-month weight loss program consisting of energy restriction (1,200 kcal) in combination with phentermine hydrocholoride (Fastin) treatment evaluated changes in plasma leptin, insulin, and glucose concentrations in 39 obese post-menopausal women (body mass index 30-38 kg/m2). Values for these parameters were correlated with plasma lipids concentrations and body composition measurements previously reported for this population. Over 6 months, participants had a 9% weight loss (P < 0.001) and a 9% reduction in body mass index (P < 0.001) compared to baseline with a 20% reduction in total fat mass and 25.8% in trunk fat (P < 0.001). Plasma leptin levels were reduced by 27% (P < 0.001) at 3 months and by 32% (P < 0.001) at 6 months. In contrast, plasma glucose and insulin levels did not change over time. Significant positive correlations tions were found between changes in plasma leptin and changes in LDL cholesterol (r = 0.366), weight (r = 0.570) and trunk fat (r = 0.362) over 6 months indicating that reductions in leptin are associated with improved parameters in plasma lipids and body composition.

Original languageEnglish (US)
Pages (from-to)60-67
Number of pages8
JournalJournal of Applied Research
Volume4
Issue number1
StatePublished - 2004

Fingerprint

Leptin
Weight Loss
Serum
Fats
Body Composition
Body Mass Index
Phentermine
Insulin
Weight Reduction Programs
Glucose
LDL Cholesterol
Lipids
Weights and Measures
Population

Keywords

  • Body composition
  • Insulin
  • Leptin
  • Plasma lipids
  • Post-menopausal women
  • Weight reduction

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology

Cite this

Cordero-MacIntyre, Z. R., Metghalchi, S., Rosen, J., Peters, W., Lohman, T. G., & Fernandez, M. L. (2004). Impact of weight loss on serum leptin in obese postmenopausal women. Journal of Applied Research, 4(1), 60-67.

Impact of weight loss on serum leptin in obese postmenopausal women. / Cordero-MacIntyre, Zaida R.; Metghalchi, Shiva; Rosen, Jason; Peters, Warren; Lohman, Timothy G; Fernandez, Maria Luz.

In: Journal of Applied Research, Vol. 4, No. 1, 2004, p. 60-67.

Research output: Contribution to journalArticle

Cordero-MacIntyre, ZR, Metghalchi, S, Rosen, J, Peters, W, Lohman, TG & Fernandez, ML 2004, 'Impact of weight loss on serum leptin in obese postmenopausal women', Journal of Applied Research, vol. 4, no. 1, pp. 60-67.
Cordero-MacIntyre ZR, Metghalchi S, Rosen J, Peters W, Lohman TG, Fernandez ML. Impact of weight loss on serum leptin in obese postmenopausal women. Journal of Applied Research. 2004;4(1):60-67.
Cordero-MacIntyre, Zaida R. ; Metghalchi, Shiva ; Rosen, Jason ; Peters, Warren ; Lohman, Timothy G ; Fernandez, Maria Luz. / Impact of weight loss on serum leptin in obese postmenopausal women. In: Journal of Applied Research. 2004 ; Vol. 4, No. 1. pp. 60-67.
@article{8254984012a24a76bf1f6ca56f716b37,
title = "Impact of weight loss on serum leptin in obese postmenopausal women",
abstract = "A 6-month weight loss program consisting of energy restriction (1,200 kcal) in combination with phentermine hydrocholoride (Fastin) treatment evaluated changes in plasma leptin, insulin, and glucose concentrations in 39 obese post-menopausal women (body mass index 30-38 kg/m2). Values for these parameters were correlated with plasma lipids concentrations and body composition measurements previously reported for this population. Over 6 months, participants had a 9{\%} weight loss (P < 0.001) and a 9{\%} reduction in body mass index (P < 0.001) compared to baseline with a 20{\%} reduction in total fat mass and 25.8{\%} in trunk fat (P < 0.001). Plasma leptin levels were reduced by 27{\%} (P < 0.001) at 3 months and by 32{\%} (P < 0.001) at 6 months. In contrast, plasma glucose and insulin levels did not change over time. Significant positive correlations tions were found between changes in plasma leptin and changes in LDL cholesterol (r = 0.366), weight (r = 0.570) and trunk fat (r = 0.362) over 6 months indicating that reductions in leptin are associated with improved parameters in plasma lipids and body composition.",
keywords = "Body composition, Insulin, Leptin, Plasma lipids, Post-menopausal women, Weight reduction",
author = "Cordero-MacIntyre, {Zaida R.} and Shiva Metghalchi and Jason Rosen and Warren Peters and Lohman, {Timothy G} and Fernandez, {Maria Luz}",
year = "2004",
language = "English (US)",
volume = "4",
pages = "60--67",
journal = "Journal of Applied Research",
issn = "1537-064X",
publisher = "The Journal of Applied Research",
number = "1",

}

TY - JOUR

T1 - Impact of weight loss on serum leptin in obese postmenopausal women

AU - Cordero-MacIntyre, Zaida R.

AU - Metghalchi, Shiva

AU - Rosen, Jason

AU - Peters, Warren

AU - Lohman, Timothy G

AU - Fernandez, Maria Luz

PY - 2004

Y1 - 2004

N2 - A 6-month weight loss program consisting of energy restriction (1,200 kcal) in combination with phentermine hydrocholoride (Fastin) treatment evaluated changes in plasma leptin, insulin, and glucose concentrations in 39 obese post-menopausal women (body mass index 30-38 kg/m2). Values for these parameters were correlated with plasma lipids concentrations and body composition measurements previously reported for this population. Over 6 months, participants had a 9% weight loss (P < 0.001) and a 9% reduction in body mass index (P < 0.001) compared to baseline with a 20% reduction in total fat mass and 25.8% in trunk fat (P < 0.001). Plasma leptin levels were reduced by 27% (P < 0.001) at 3 months and by 32% (P < 0.001) at 6 months. In contrast, plasma glucose and insulin levels did not change over time. Significant positive correlations tions were found between changes in plasma leptin and changes in LDL cholesterol (r = 0.366), weight (r = 0.570) and trunk fat (r = 0.362) over 6 months indicating that reductions in leptin are associated with improved parameters in plasma lipids and body composition.

AB - A 6-month weight loss program consisting of energy restriction (1,200 kcal) in combination with phentermine hydrocholoride (Fastin) treatment evaluated changes in plasma leptin, insulin, and glucose concentrations in 39 obese post-menopausal women (body mass index 30-38 kg/m2). Values for these parameters were correlated with plasma lipids concentrations and body composition measurements previously reported for this population. Over 6 months, participants had a 9% weight loss (P < 0.001) and a 9% reduction in body mass index (P < 0.001) compared to baseline with a 20% reduction in total fat mass and 25.8% in trunk fat (P < 0.001). Plasma leptin levels were reduced by 27% (P < 0.001) at 3 months and by 32% (P < 0.001) at 6 months. In contrast, plasma glucose and insulin levels did not change over time. Significant positive correlations tions were found between changes in plasma leptin and changes in LDL cholesterol (r = 0.366), weight (r = 0.570) and trunk fat (r = 0.362) over 6 months indicating that reductions in leptin are associated with improved parameters in plasma lipids and body composition.

KW - Body composition

KW - Insulin

KW - Leptin

KW - Plasma lipids

KW - Post-menopausal women

KW - Weight reduction

UR - http://www.scopus.com/inward/record.url?scp=6444237070&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=6444237070&partnerID=8YFLogxK

M3 - Article

VL - 4

SP - 60

EP - 67

JO - Journal of Applied Research

JF - Journal of Applied Research

SN - 1537-064X

IS - 1

ER -