Impaired exercise performance in systemic sclerosis and its clinical correlations

G. Cuomo, C. Santoriello, F. Polverino, L. Ruocco, G. Valentini, M. Polverino

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Objectives: To investigate the prevalence of impaired exercise performance as assessed by a standardized cardiopulmonary exercise test (CPET) in systemic sclerosis (SSc) and to identify the associated disease features. Methods: Forty-six SSc patients were enrolled and evaluated for clinical and serological SSc subset, extent of skin and internal organ involvement, and disease activity and severity. Exercise performance was subsequently evaluated in these patients and in 23 healthy individuals matched for sex and age, using a standardized CPET. Results: Exercise performance, measured by maximum oxygen uptake ( max < 80 of predicted value), was found to be impaired in 4346 patients. Stepwise regression analysis showed that max adjusted for body weight ( maxkg) was independently correlated with the severity of heart (p 0.001) and lung (p 0.013) involvement, left ventricular diastolic dysfunction (p 0.009), and the Health Assessment Questionnaire Disability Index (HAQ-DI) score (p 0.016). Conclusions: This study demonstrates that physical disability contributes significantly to the development of impaired exercise performance in SSc patients. Cardiopulmonary exercise testing may be included among the battery of tests used to determine the severity of SSc.

Original languageEnglish (US)
Pages (from-to)330-335
Number of pages6
JournalScandinavian Journal of Rheumatology
Issue number4
StatePublished - Aug 2010
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology


Dive into the research topics of 'Impaired exercise performance in systemic sclerosis and its clinical correlations'. Together they form a unique fingerprint.

Cite this