Impaired platelet mitochondrial activity in Alzheimer's disease and mild cognitive impairment

Jon Valla, Lonnie Schneider, Tracy Niedzielko, Keith D. Coon, Richard Caselli, Marwan N. Sabbagh, Geoffrey L Ahern, Leslie Baxter, Gene E Alexander, Douglas G. Walker, Eric M. Reiman

Research output: Contribution to journalArticle

113 Citations (Scopus)

Abstract

Mitochondrial abnormalities are found in Alzheimer's disease (AD), but previous reports have not examined at-risk groups. In subjects with AD, mild cognitive impairment (MCI), and non-demented aged controls, platelet and lymphocyte mitochondria were isolated and analyzed for Complexes I, III, and IV of the electron transport chain. Western blots were used to control for differential enrichment of samples. Results demonstrated significant declines in Complexes III and IV in AD, and a significant decline in Complex IV in MCI. This report confirms mitochondrial deficiencies in AD, extends them to MCI, and suggests they are present at the earliest symptomatic stages of disease.

Original languageEnglish (US)
Pages (from-to)323-330
Number of pages8
JournalMitochondrion
Volume6
Issue number6
DOIs
StatePublished - Dec 2006

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Alzheimer Disease
Blood Platelets
Electron Transport Complex III
Electron Transport
Mitochondria
Western Blotting
Lymphocytes
Cognitive Dysfunction

Keywords

  • Alzheimer's disease
  • At-risk population
  • Cytochrome oxidase
  • Cytochrome reductase
  • Electron transport chain
  • Mild cognitive impairment

ASJC Scopus subject areas

  • Biophysics

Cite this

Valla, J., Schneider, L., Niedzielko, T., Coon, K. D., Caselli, R., Sabbagh, M. N., ... Reiman, E. M. (2006). Impaired platelet mitochondrial activity in Alzheimer's disease and mild cognitive impairment. Mitochondrion, 6(6), 323-330. https://doi.org/10.1016/j.mito.2006.10.004

Impaired platelet mitochondrial activity in Alzheimer's disease and mild cognitive impairment. / Valla, Jon; Schneider, Lonnie; Niedzielko, Tracy; Coon, Keith D.; Caselli, Richard; Sabbagh, Marwan N.; Ahern, Geoffrey L; Baxter, Leslie; Alexander, Gene E; Walker, Douglas G.; Reiman, Eric M.

In: Mitochondrion, Vol. 6, No. 6, 12.2006, p. 323-330.

Research output: Contribution to journalArticle

Valla, J, Schneider, L, Niedzielko, T, Coon, KD, Caselli, R, Sabbagh, MN, Ahern, GL, Baxter, L, Alexander, GE, Walker, DG & Reiman, EM 2006, 'Impaired platelet mitochondrial activity in Alzheimer's disease and mild cognitive impairment', Mitochondrion, vol. 6, no. 6, pp. 323-330. https://doi.org/10.1016/j.mito.2006.10.004
Valla J, Schneider L, Niedzielko T, Coon KD, Caselli R, Sabbagh MN et al. Impaired platelet mitochondrial activity in Alzheimer's disease and mild cognitive impairment. Mitochondrion. 2006 Dec;6(6):323-330. https://doi.org/10.1016/j.mito.2006.10.004
Valla, Jon ; Schneider, Lonnie ; Niedzielko, Tracy ; Coon, Keith D. ; Caselli, Richard ; Sabbagh, Marwan N. ; Ahern, Geoffrey L ; Baxter, Leslie ; Alexander, Gene E ; Walker, Douglas G. ; Reiman, Eric M. / Impaired platelet mitochondrial activity in Alzheimer's disease and mild cognitive impairment. In: Mitochondrion. 2006 ; Vol. 6, No. 6. pp. 323-330.
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