Impaired platelet mitochondrial activity in Alzheimer's disease and mild cognitive impairment

Jon Valla, Lonnie Schneider, Tracy Niedzielko, Keith D. Coon, Richard Caselli, Marwan N. Sabbagh, Geoffrey L. Ahern, Leslie Baxter, Gene Alexander, Douglas G. Walker, Eric M. Reiman

Research output: Contribution to journalArticlepeer-review

121 Scopus citations

Abstract

Mitochondrial abnormalities are found in Alzheimer's disease (AD), but previous reports have not examined at-risk groups. In subjects with AD, mild cognitive impairment (MCI), and non-demented aged controls, platelet and lymphocyte mitochondria were isolated and analyzed for Complexes I, III, and IV of the electron transport chain. Western blots were used to control for differential enrichment of samples. Results demonstrated significant declines in Complexes III and IV in AD, and a significant decline in Complex IV in MCI. This report confirms mitochondrial deficiencies in AD, extends them to MCI, and suggests they are present at the earliest symptomatic stages of disease.

Original languageEnglish (US)
Pages (from-to)323-330
Number of pages8
JournalMitochondrion
Volume6
Issue number6
DOIs
StatePublished - Dec 2006

Keywords

  • Alzheimer's disease
  • At-risk population
  • Cytochrome oxidase
  • Cytochrome reductase
  • Electron transport chain
  • Mild cognitive impairment

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Cell Biology

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