Implications and concepts of polyamine-nucleic acid interactions

Burt G.F. Feuerstein, L. D. Williams, H. S. Basu, L. J. Marton

Research output: Contribution to journalArticle

174 Scopus citations

Abstract

Modeling, x-ray diffraction, and solution studies have contributed to the understanding of interactions between polyamines and nucleic acids. Polyamines stabilize a variety of unusual DNA structures and conformations in vitro, including both the left-handed Z and the right-handed A DNA. In addition, polyamines condense DNA and may be important in bending specific sequences. Investigations into the mechanisms of these effects provide support for both specific and nonspecific interactions between polyamines and DNA. Although exact relationships between the binding of polyamines and conformational changes in nucleic acids ara still being clarified, polyamines remain important candidates for regulators of DNA conformation in vivo.

Original languageEnglish (US)
Pages (from-to)37-47
Number of pages11
JournalJournal of Cellular Biochemistry
Volume46
Issue number1
Publication statusPublished - 1991
Externally publishedYes

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Keywords

  • A DNA
  • Anthracyclines
  • B DNA
  • DNA
  • DNA bending
  • DNA conformation
  • DNA/ligand interactions
  • Nucleic acid conformation
  • Polyamine function
  • Polyamines
  • Spermidine
  • Spermine
  • Z DNA

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

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