Implications of the X-ray structure of deamino-oxytocin to agonist/antagonist-receptor interactions

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48 Scopus citations

Abstract

Abstract: A recent Science article demonstrating the X-ray structure of an oxytocin analog indicates low-energy interconversion of the disulfide between a right-handed and left-handed helicity, as well as conformational flexibility for the side-chain Asn5 and Ile3 residues. These results and other corresponding biological data support a hypothesis which, Victor Hruby explains, suggests that oxytocin antagonist analogs interact with the oxytocin receptor in a different manner to the interaction of oxytocin agonists. This may have general implications for agonist/antagonist interactions and may aid rational analog design.

Original languageEnglish (US)
Pages (from-to)336-339
Number of pages4
JournalTrends in Pharmacological Sciences
Volume8
Issue number9
DOIs
StatePublished - Sep 1987

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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