Improved outcomes of patients with end-stage cystic fibrosis requiring invasive mechanical ventilation for acute respiratory failure

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6 Scopus citations

Abstract

Study Objectives The aim of this study was to determine the effects of an antibiotic strategy with intravenous (IV) continuous infusion of a β-lactam (CIBL) antibiotic and high-dose extended-interval (HDEI) tobramycin upon outcomes in patients with cystic fibrosis (CF) requiring invasive mechanical ventilation (IMV) for acute respiratory failure. Design The study was a retrospective review from June 1, 2006, to December 1, 2010, of patients at a university hospital with an adult CF center. Results The study population included adult CF patients requiring IMV. A total of 15 hospitalizations with IMV episodes were reviewed, involving 10 adult (31.4±11.1 years) CF patients with end-stage lung disease (FEV 1 = 23.6±7.8% predicted) and malnutrition (body mass index = 20.5±3.1). Each patient survived to discharge and to follow-up 6 months later without the need for lung transplantation during the study period. Conclusions A novel antibiotic strategy with a CIBL antibiotic and HDEI tobramycin improved survival in a small cohort of critically ill CF patients with end-stage lung disease and malnutrition requiring IMV.

Original languageEnglish (US)
Pages (from-to)409-415
Number of pages7
JournalLung
Volume189
Issue number5
DOIs
StatePublished - Oct 1 2011
Externally publishedYes

Keywords

  • Continuous infusion
  • Cystic fibrosis
  • Invasive mechanical ventilation
  • Pseudomonas aeruginosa
  • Respiratory failure
  • Tobramycin
  • β-Lactam antibiotic

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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