Improving tumor response to radiotherapy by targeting angiogenesis signaling pathways

Phyllis Wachsberger, Randy Burd, Adam P. Dicker

Research output: Contribution to journalReview article

31 Scopus citations

Abstract

Radiotherapy is one of the most widely used treatments for cancer; however, the development of tumor radioresistance is an ongoing problem. Agents that target tumor angiogenesis are being used in combination with radiotherapy to improve the therapeutic index without a clear understanding of how these agents may affect radiosensitization. This article discusses recently published studies that may shed some light on the underlying signaling mechanisms that are involved in the interactions of antiangiogenic agents with ionizing radiation.

Original languageEnglish (US)
Pages (from-to)1039-1057
Number of pages19
JournalHematology/Oncology Clinics of North America
Volume18
Issue number5
DOIs
StatePublished - Oct 1 2004

ASJC Scopus subject areas

  • Hematology
  • Oncology

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