In-plane scatterometry of a small caliber blood column

Arthur Lompado, Matthew H. Smith, Lloyd W. Hillman, Kurt R Denninghoff

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

The scattering of He-Ne laser light incident on a flowing column of whole human blood has been measured and analyzed. An automated scatterometer whose sample chamber simulates a small caliber blood vessel was used to perform the measurements and is described. Angular scattered light distributions due to flowing blood columns for two independently varied parameters, blood oxygenation and hemoglobin concentration, are presented. It is found that the dependence of the scattering distribution on blood oxygenation is minimal while the dependence on hemoglobin concentration is strong. A nominally transparent sample of human plasma has also been investigated to quantify its scattering characteristics. The whole blood scattering results are compared to theoretical predictions obtained using a Monte Carlo simulation employing the Mie single particle phase function and macroscopic transport coefficients obtained from published literature. The best correlation was found when the largest published scattering coefficient was employed in the simulation. However, a strong correlation between the measured and predicted scattering distributions was only obtained when unphysically high values of the scattering coefficient were used in the simulation.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
PublisherSociety of Photo-Optical Instrumentation Engineers
Pages44-53
Number of pages10
Volume3923
StatePublished - 2000
Externally publishedYes
EventOptical Diagnostics of Biological Fluids V - San Jose, CA, USA
Duration: Jan 27 2000Jan 27 2000

Other

OtherOptical Diagnostics of Biological Fluids V
CitySan Jose, CA, USA
Period1/27/001/27/00

Fingerprint

blood
Blood
Scattering
scattering
oxygenation
scattering coefficients
hemoglobin
Oxygenation
Hemoglobin
scatterometers
simulation
blood vessels
Plasma (human)
Blood vessels
transport properties
chambers
predictions
lasers
Lasers

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Lompado, A., Smith, M. H., Hillman, L. W., & Denninghoff, K. R. (2000). In-plane scatterometry of a small caliber blood column. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 3923, pp. 44-53). Society of Photo-Optical Instrumentation Engineers.

In-plane scatterometry of a small caliber blood column. / Lompado, Arthur; Smith, Matthew H.; Hillman, Lloyd W.; Denninghoff, Kurt R.

Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3923 Society of Photo-Optical Instrumentation Engineers, 2000. p. 44-53.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Lompado, A, Smith, MH, Hillman, LW & Denninghoff, KR 2000, In-plane scatterometry of a small caliber blood column. in Proceedings of SPIE - The International Society for Optical Engineering. vol. 3923, Society of Photo-Optical Instrumentation Engineers, pp. 44-53, Optical Diagnostics of Biological Fluids V, San Jose, CA, USA, 1/27/00.
Lompado A, Smith MH, Hillman LW, Denninghoff KR. In-plane scatterometry of a small caliber blood column. In Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3923. Society of Photo-Optical Instrumentation Engineers. 2000. p. 44-53
Lompado, Arthur ; Smith, Matthew H. ; Hillman, Lloyd W. ; Denninghoff, Kurt R. / In-plane scatterometry of a small caliber blood column. Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3923 Society of Photo-Optical Instrumentation Engineers, 2000. pp. 44-53
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