TY - JOUR
T1 - In search of susceptibility genes for type 2 diabetes in West Africa
T2 - The design and results of the first phase of the AADM study
AU - Rotimi, Charles N.
AU - Dunston, Georgia M.
AU - Berg, Kate
AU - Akinsete, Omobosola
AU - Amoah, Albert
AU - Owusu, Samuel
AU - Acheampong, Joseph
AU - Boateng, Kofi
AU - Oli, Johnnie
AU - Okafor, Godfrey
AU - Onyenekwe, Belonwu
AU - Osotimehin, Babatunde
AU - Abbiyesuku, Fayeofori
AU - Johnson, Thomas
AU - Fasanmade, Olufemi
AU - Furbert-Harris, Paulette
AU - Kittles, Rick
AU - Vekich, Mirjana
AU - Adegoke, Olufemi
AU - Bonney, George
AU - Collins, Francis
N1 - Funding Information:
Support for AADM study is provided by NIH grant No. 3T37TW00041–03S2 from the Office of Research on Minority Health. This project is also support in part by the National Human Genome Research Institute (NHGRI).
PY - 2001
Y1 - 2001
N2 - PURPOSE: The purpose of this study is to map type 2 diabetes susceptibility genes in West African ancestral populations of African-Americans, through an international collaboration between West African and US investigators. DESIGN AND METHODS: Affected sib-pairs (ASP) along with unaffected spouse controls are being enrolled and examined in West Africa, with two sites established in Ghana (Accra and Kumasi) and three in Nigeria (Enugu, Ibadan, and Lagos). Eligible participants are invited to study clinics to obtain detailed epidemiologic, family, and medical history information. Blood samples are drawn from each participant to measure glucose, insulin, C-peptide, total cholesterol, LDL, HDL, triglycerides, albumin, creatinine, urea, uric acid, total calcium and to detect autoantibodies to glutamic acid decarboxylase (GAD). DNA is isolated from frozen white blood cells obtained from 20 ml of EDTA whole blood samples. RESULTS: With full informed consent, 162 individuals from 78 families have been enrolled and examined since the Africa America Diabetes Mellitus (AADM) study began in June of 1997. Logistics of field examinations and specimen shipping have been successfully established. At the end of the third year of field activity (September 2000) the AADM study will have enrolled and performed comprehensive examination on 400 ASP with type 2 diabetes, for a minimum of 800 cases and 200 controls from Ghana and Nigeria. At the current participation rate, the goal of 400 sib-pairs and 200 controls will be met before the scheduled closing date. CONCLUSIONS: The AADM study will create a comprehensive epidemiologic and genetic resource that will facilitate a powerful genome-wide search for West African susceptibility genes to type 2 diabetes.
AB - PURPOSE: The purpose of this study is to map type 2 diabetes susceptibility genes in West African ancestral populations of African-Americans, through an international collaboration between West African and US investigators. DESIGN AND METHODS: Affected sib-pairs (ASP) along with unaffected spouse controls are being enrolled and examined in West Africa, with two sites established in Ghana (Accra and Kumasi) and three in Nigeria (Enugu, Ibadan, and Lagos). Eligible participants are invited to study clinics to obtain detailed epidemiologic, family, and medical history information. Blood samples are drawn from each participant to measure glucose, insulin, C-peptide, total cholesterol, LDL, HDL, triglycerides, albumin, creatinine, urea, uric acid, total calcium and to detect autoantibodies to glutamic acid decarboxylase (GAD). DNA is isolated from frozen white blood cells obtained from 20 ml of EDTA whole blood samples. RESULTS: With full informed consent, 162 individuals from 78 families have been enrolled and examined since the Africa America Diabetes Mellitus (AADM) study began in June of 1997. Logistics of field examinations and specimen shipping have been successfully established. At the end of the third year of field activity (September 2000) the AADM study will have enrolled and performed comprehensive examination on 400 ASP with type 2 diabetes, for a minimum of 800 cases and 200 controls from Ghana and Nigeria. At the current participation rate, the goal of 400 sib-pairs and 200 controls will be met before the scheduled closing date. CONCLUSIONS: The AADM study will create a comprehensive epidemiologic and genetic resource that will facilitate a powerful genome-wide search for West African susceptibility genes to type 2 diabetes.
KW - Genes
KW - Linkage
KW - Sib-Pairs
KW - Type 2 diabetes
KW - West Africa
UR - http://www.scopus.com/inward/record.url?scp=0035174798&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035174798&partnerID=8YFLogxK
U2 - 10.1016/S1047-2797(00)00180-0
DO - 10.1016/S1047-2797(00)00180-0
M3 - Article
C2 - 11164120
AN - SCOPUS:0035174798
VL - 11
SP - 51
EP - 58
JO - Annals of Epidemiology
JF - Annals of Epidemiology
SN - 1047-2797
IS - 1
ER -