In situ fabrication of three-dimensional chemical patterns in fused silica separation capillaries with polymerized phospholipids

Eric E. Ross, Elisabeth Mansfield, Yiding Huang, Craig A. Aspinwall

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

We report a new molecular approach for in situ generation of micron scale, chemically and biochemically functionalized patterns inside three-dimensional, completely enclosed fluidic channels. The formation of chemical patterns is based upon a combination of lipid bilayer self-assembly and UV photopolymerization of photoreactive, cross-linkable phospholipids. Using this approach, we have functionalized capillaries of varying inner diameters with a range of chemistries useful for protein and peptide immobilization. Here, we demonstrate the ability to produce small molecule and protein-based chemical patterns.

Original languageEnglish (US)
Pages (from-to)16756-16757
Number of pages2
JournalJournal of the American Chemical Society
Volume127
Issue number48
DOIs
StatePublished - Dec 7 2005

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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