In Utero Epstein-Barr Virus (Infectious Mononucleosis) Infection

Gerald N. Goldberg, Vincent A. Fulginiti, C. George Ray, Peggy Ferry, James F. Jones, Linda Minnich, Harold E Cross

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A male infant infected in utero with Epstein-Barr virus (EBV) demonstrated a syndrome of multiple congenital anomalies (micrognathia, cryptorchidism, central cataracts), hypotonia, thrombocytopenia, persistent monocytosis, proteinuria, and multiple areas of metaphysitis at birth. Lymphocytes were Epstein-Barr nuclear antigen (EBNA) positive (18%) and persisted in culture for three months. He had antibody to early antigen (anti-EA), IgM-viral capsid (anti-VCA), and EBNA (anti-EBNA) detectable at 22 days of age. All attempts to isolate infectious agents or to serologically identify other infectious causes for his syndrome were negative.

Original languageEnglish (US)
Pages (from-to)1579-1581
Number of pages3
JournalJournal of the American Medical Association
Issue number14
Publication statusPublished - Oct 2 1981


ASJC Scopus subject areas

  • Medicine(all)

Cite this

Goldberg, G. N., Fulginiti, V. A., Ray, C. G., Ferry, P., Jones, J. F., Minnich, L., & Cross, H. E. (1981). In Utero Epstein-Barr Virus (Infectious Mononucleosis) Infection. Journal of the American Medical Association, 246(14), 1579-1581.