In vitro and in vivo modulation of vascular barrier integrity by sphingosine 1-phosphate: Mechanistic insights

Bryan J. McVerry, Joe G.N. Garcia

Research output: Contribution to journalReview article

178 Scopus citations

Abstract

Sphingosine 1-phosphate (S1P), a biologically active lipid growth factor, induces robust endothelial cell activation resulting in cellular locomotion, vascular maturation and angiogenesis. Recent work by our laboratory has demonstrated S1P to enhance the cellular barrier function of the vascular endothelium. S1P-induced modulation of vascular permeability is effected through profound cytoskeletal reorganization initiated by cell surface receptor-mediated G protein activation and downstream signaling via the Rho family of small GTPases. The details of the downstream signaling mechanism remain an active area of in vitro investigation. Translational investigation suggests a profound impact of S1P administration in the modulation of edema formation in disease state manifest as acute inflammatory lung injury in which increased vascular permeability is a hallmark feature. These data support an exciting potential therapeutic role for S1P in vascular barrier enhancement necessary for the treatment of critically ill patients.

Original languageEnglish (US)
Pages (from-to)131-139
Number of pages9
JournalCellular Signalling
Volume17
Issue number2
DOIs
StatePublished - Feb 1 2005
Externally publishedYes

Keywords

  • Cadherin
  • Cortactin
  • Cytoskeleton
  • Endothelial permeability
  • MLCK
  • Rac GTPase
  • Rho GTPase

ASJC Scopus subject areas

  • Cell Biology

Fingerprint Dive into the research topics of 'In vitro and in vivo modulation of vascular barrier integrity by sphingosine 1-phosphate: Mechanistic insights'. Together they form a unique fingerprint.

  • Cite this