In vitro chemoenzymatic and in vivo biocatalytic syntheses of new beauvericin analogues

Diana Matthes, Lennart Richter, Jane Müller, Alexander Denisiuk, Sven C. Feifel, Yuquan Xu, Patricia Espinosa-Artiles, Roderich D. Süssmuth, István Molnár

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

New beauvericins have been synthesized using the nonribosomal peptide synthetase BbBEAS from the entomopathogenic fungus Beauveria bassiana. Chemical diversity was generated by in vitro chemoenzymatic and in vivo whole cell biocatalytic syntheses using either a B. bassiana mutant or an E. coli strain expressing the bbBeas gene.

Original languageEnglish (US)
Pages (from-to)5674-5676
Number of pages3
JournalChemical Communications
Volume48
Issue number45
DOIs
StatePublished - May 9 2012

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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    Matthes, D., Richter, L., Müller, J., Denisiuk, A., Feifel, S. C., Xu, Y., Espinosa-Artiles, P., Süssmuth, R. D., & Molnár, I. (2012). In vitro chemoenzymatic and in vivo biocatalytic syntheses of new beauvericin analogues. Chemical Communications, 48(45), 5674-5676. https://doi.org/10.1039/c2cc31669b