In vitro chemoenzymatic and in vivo biocatalytic syntheses of new beauvericin analogues

Diana Matthes, Lennart Richter, Jane Müller, Alexander Denisiuk, Sven C. Feifel, Yuquan Xu, Patricia Espinosa-Artiles, Roderich D. Süssmuth, Istvan Molnar

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

New beauvericins have been synthesized using the nonribosomal peptide synthetase BbBEAS from the entomopathogenic fungus Beauveria bassiana. Chemical diversity was generated by in vitro chemoenzymatic and in vivo whole cell biocatalytic syntheses using either a B. bassiana mutant or an E. coli strain expressing the bbBeas gene.

Original languageEnglish (US)
Pages (from-to)5674-5676
Number of pages3
JournalChemical Communications
Volume48
Issue number45
DOIs
StatePublished - Jun 7 2012

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Peptide Synthases
Fungi
Escherichia coli
Peptides
Genes
beauvericin

ASJC Scopus subject areas

  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Catalysis
  • Chemistry(all)

Cite this

In vitro chemoenzymatic and in vivo biocatalytic syntheses of new beauvericin analogues. / Matthes, Diana; Richter, Lennart; Müller, Jane; Denisiuk, Alexander; Feifel, Sven C.; Xu, Yuquan; Espinosa-Artiles, Patricia; Süssmuth, Roderich D.; Molnar, Istvan.

In: Chemical Communications, Vol. 48, No. 45, 07.06.2012, p. 5674-5676.

Research output: Contribution to journalArticle

Matthes, D, Richter, L, Müller, J, Denisiuk, A, Feifel, SC, Xu, Y, Espinosa-Artiles, P, Süssmuth, RD & Molnar, I 2012, 'In vitro chemoenzymatic and in vivo biocatalytic syntheses of new beauvericin analogues', Chemical Communications, vol. 48, no. 45, pp. 5674-5676. https://doi.org/10.1039/c2cc31669b
Matthes D, Richter L, Müller J, Denisiuk A, Feifel SC, Xu Y et al. In vitro chemoenzymatic and in vivo biocatalytic syntheses of new beauvericin analogues. Chemical Communications. 2012 Jun 7;48(45):5674-5676. https://doi.org/10.1039/c2cc31669b
Matthes, Diana ; Richter, Lennart ; Müller, Jane ; Denisiuk, Alexander ; Feifel, Sven C. ; Xu, Yuquan ; Espinosa-Artiles, Patricia ; Süssmuth, Roderich D. ; Molnar, Istvan. / In vitro chemoenzymatic and in vivo biocatalytic syntheses of new beauvericin analogues. In: Chemical Communications. 2012 ; Vol. 48, No. 45. pp. 5674-5676.
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