In vitro effects of zinc chloride on spontaneous sheep red blood cell (e) rosette formation by lymphocytes from cancer patients and normal subjects

L. J. Mcmahon, David W Montgomery, Ann Guschewsky, A. H. Woods, C. F. Zukoski

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The in vitro spontaneous formation of sheep red blood cell (SRBC) (E) rosettes by peripheral blood lymphocytes is altered in vitro by the addition of micro-molar quantities of zinc chloride. Appropriate concentrations of zinc chloride cause marked enhancement of rosette formation, both in normal subjects and in cancer patients with low initial E rosette values. The effect is dependent upon zinc treatment of the lymphocyte and not the SRBC. Other zinc-induced effects on E rosettes include retardation of temperature-dependent spontaneous decay, increased mechanical stability due to enhanced SRBC-lymphocyte bonding, and retardation of " capping." The formation of EAC rosettes is not altered by the presence of zinc.

Original languageEnglish (US)
Pages (from-to)53-67
Number of pages15
JournalImmunological Investigations
Issue number1-2
Publication statusPublished - 1976


ASJC Scopus subject areas

  • Immunology

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