In vitro evaluation and finite element simulation of drug release from polydiacetylene-polyethylene glycol stearate nanovesicles

Caixin Guo, Like Zeng, Shaoqin Liu, Qi Chen, Zhifei Dai, Xiaoyi Wu

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Vesicles comprised of 10,12-pentacosadiynoic acid (PCDA) were modified, using polyethylene glycol 40 stearate (PEG40S), and crosslinked by ultraviolet (UV) irradiation to create polymerized nanovesicles for sustained drug release. Paclitaxel, a water-insoluble compound widely used in cancer chemotherapy, was used as a model drug to examine the physicochemical stability and release profiles of PCDA/PEG40S nanovesicles. TEM analysis revealed the formation of paclitaxelencapsulated PCDA/PEG40S nanovesicles of 40 to 200 nm in size. Upon the addition of ethanol, instantaneous releases of paclitaxel in the amount of 28 μg/mL from polymerized PCDA/PEG40S nanovesicles and 108 μg/ml from unpolymerized ones were observed. This suggested the noncomplete drug release from polymerized PCDA/PEG40S nanovesicles due to their enhanced physicochemical stability by ultraviolet irradiation-induced polymerization, if compared to unpolymerized ones. An in vitro study demonstrated that an accumulative release of 2401±3.1% and 8.1±1.7% of paclitaxel was obtained within 24 hrs from nanovesicles comprised of PCDA/PEG40S at a 9:1 and 7:3 molar ratio, respectively. A finite element model that considered the diffusion-driven releases and the reversible drug-vesicle interaction captured the sustained release of paclitaxel from polymerized PCDA/PEG40S nanovesicles. PCDA/PEG40S nanovesicles capable of sustained release and with enhanced physicochemical stability thus possess great potential for applications in drug release.

Original languageEnglish (US)
Pages (from-to)245-251
Number of pages7
JournalJournal of Nanoscience and Nanotechnology
Volume12
Issue number1
DOIs
StatePublished - 2012

Fingerprint

Stearates
stearates
Polyethylene glycols
glycols
polyethylenes
drugs
acids
Acids
evaluation
Paclitaxel
Pharmaceutical Preparations
simulation
Irradiation
Drug interactions
irradiation
Chemotherapy
12-pentacosadiynoic acid 10
polydiacetylene
Drug Liberation
In Vitro Techniques

Keywords

  • Drug release
  • Finite element simulation
  • Polydiacetylene
  • Polyethylene glycol stearate

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Chemistry(all)
  • Materials Science(all)
  • Bioengineering
  • Biomedical Engineering

Cite this

In vitro evaluation and finite element simulation of drug release from polydiacetylene-polyethylene glycol stearate nanovesicles. / Guo, Caixin; Zeng, Like; Liu, Shaoqin; Chen, Qi; Dai, Zhifei; Wu, Xiaoyi.

In: Journal of Nanoscience and Nanotechnology, Vol. 12, No. 1, 2012, p. 245-251.

Research output: Contribution to journalArticle

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