In vitro immunotoxicology and immunopharmacology

studies on drugs of abuse

Radhakrishna M. Pillai, Ronald R Watson

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The application of immunotoxicology to the toxicologie assessment of drugs of abuse is a field of increasing importance. Interest in the effects of drugs of abuse on the immune system has greatly increased as a result of the AIDS epidemic. If drugs of abuse compromise the immune system, their use may well become a predisposing factor in the development or enhancement of AIDS in high-risk groups. Therefore development and validation of newer methods of assessment of immunotoxicology and their adaptation to routine analysis is an absolute necessity. An important feature in toxicology in general, and in immunotoxicology in particular, is the need to develop in vitro assessment systems. Recent research has provided newer models, data on correlations of immune function variables, and a better understanding of the biologic relevance of certain immune function parameters. This paper analyzes these features in relation to the role of drugs of abuse in the modulation and alteration of the immune system and reviews the various in vitro techniques that could be used to evaluate immunotoxicity.

Original languageEnglish (US)
Pages (from-to)269-283
Number of pages15
JournalToxicology Letters
Volume53
Issue number3
DOIs
StatePublished - 1990

Fingerprint

Street Drugs
Immune system
Immune System
Acquired Immunodeficiency Syndrome
Causality
Toxicology
Modulation
In Vitro Techniques
Research

Keywords

  • B-cells
  • Cytokines
  • Immunoglobulin synthesis
  • Natural killer cells
  • T-cells
  • Xenobiotics

ASJC Scopus subject areas

  • Toxicology

Cite this

In vitro immunotoxicology and immunopharmacology : studies on drugs of abuse. / Pillai, Radhakrishna M.; Watson, Ronald R.

In: Toxicology Letters, Vol. 53, No. 3, 1990, p. 269-283.

Research output: Contribution to journalArticle

@article{56511854b5cb40319cc5e36cc3dba289,
title = "In vitro immunotoxicology and immunopharmacology: studies on drugs of abuse",
abstract = "The application of immunotoxicology to the toxicologie assessment of drugs of abuse is a field of increasing importance. Interest in the effects of drugs of abuse on the immune system has greatly increased as a result of the AIDS epidemic. If drugs of abuse compromise the immune system, their use may well become a predisposing factor in the development or enhancement of AIDS in high-risk groups. Therefore development and validation of newer methods of assessment of immunotoxicology and their adaptation to routine analysis is an absolute necessity. An important feature in toxicology in general, and in immunotoxicology in particular, is the need to develop in vitro assessment systems. Recent research has provided newer models, data on correlations of immune function variables, and a better understanding of the biologic relevance of certain immune function parameters. This paper analyzes these features in relation to the role of drugs of abuse in the modulation and alteration of the immune system and reviews the various in vitro techniques that could be used to evaluate immunotoxicity.",
keywords = "B-cells, Cytokines, Immunoglobulin synthesis, Natural killer cells, T-cells, Xenobiotics",
author = "Pillai, {Radhakrishna M.} and Watson, {Ronald R}",
year = "1990",
doi = "10.1016/0378-4274(90)90232-B",
language = "English (US)",
volume = "53",
pages = "269--283",
journal = "Toxicology Letters",
issn = "0378-4274",
publisher = "Elsevier BV",
number = "3",

}

TY - JOUR

T1 - In vitro immunotoxicology and immunopharmacology

T2 - studies on drugs of abuse

AU - Pillai, Radhakrishna M.

AU - Watson, Ronald R

PY - 1990

Y1 - 1990

N2 - The application of immunotoxicology to the toxicologie assessment of drugs of abuse is a field of increasing importance. Interest in the effects of drugs of abuse on the immune system has greatly increased as a result of the AIDS epidemic. If drugs of abuse compromise the immune system, their use may well become a predisposing factor in the development or enhancement of AIDS in high-risk groups. Therefore development and validation of newer methods of assessment of immunotoxicology and their adaptation to routine analysis is an absolute necessity. An important feature in toxicology in general, and in immunotoxicology in particular, is the need to develop in vitro assessment systems. Recent research has provided newer models, data on correlations of immune function variables, and a better understanding of the biologic relevance of certain immune function parameters. This paper analyzes these features in relation to the role of drugs of abuse in the modulation and alteration of the immune system and reviews the various in vitro techniques that could be used to evaluate immunotoxicity.

AB - The application of immunotoxicology to the toxicologie assessment of drugs of abuse is a field of increasing importance. Interest in the effects of drugs of abuse on the immune system has greatly increased as a result of the AIDS epidemic. If drugs of abuse compromise the immune system, their use may well become a predisposing factor in the development or enhancement of AIDS in high-risk groups. Therefore development and validation of newer methods of assessment of immunotoxicology and their adaptation to routine analysis is an absolute necessity. An important feature in toxicology in general, and in immunotoxicology in particular, is the need to develop in vitro assessment systems. Recent research has provided newer models, data on correlations of immune function variables, and a better understanding of the biologic relevance of certain immune function parameters. This paper analyzes these features in relation to the role of drugs of abuse in the modulation and alteration of the immune system and reviews the various in vitro techniques that could be used to evaluate immunotoxicity.

KW - B-cells

KW - Cytokines

KW - Immunoglobulin synthesis

KW - Natural killer cells

KW - T-cells

KW - Xenobiotics

UR - http://www.scopus.com/inward/record.url?scp=0025183028&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025183028&partnerID=8YFLogxK

U2 - 10.1016/0378-4274(90)90232-B

DO - 10.1016/0378-4274(90)90232-B

M3 - Article

VL - 53

SP - 269

EP - 283

JO - Toxicology Letters

JF - Toxicology Letters

SN - 0378-4274

IS - 3

ER -