In vitro measurement of chemical toxicity in complex mixtures

Robert G Arnold, Karen D. Turney, Matthew Scholz

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Pressure on water resources has forced planners to consider use of less desirable water supply alternatives. A study on the development and/or application of two types of in vitro biochemical tests for the measurement of chemical toxicity in water was carried out. Microarray technologies that may be used to anticipate whole-organism or tissue-specific responses to low-dose chemical exposure were examined. About 30 cDNA sequences were selected for inclusion in a microarray based on their previously observed up or down regulation in embryonic rat hearts exposed to TCE. The gene expression products cross reacted with other genes with sufficient sequence homology. Such non-specific hybridizations would have to be eliminated or minimized before the technology can be widely applied. This is an abstract of a paper presented at the 221st ACS National Meeting (San Diego, CA 4/1-5/2001).

Original languageEnglish (US)
Title of host publicationACS Division of Environmental Chemistry, Preprints
Pages1008-1010
Number of pages3
Volume41
Edition1
StatePublished - 2001
Event221st ACS National Meeting - San Diego, CA, United States
Duration: Apr 1 2001Apr 5 2001

Other

Other221st ACS National Meeting
CountryUnited States
CitySan Diego, CA
Period4/1/014/5/01

Fingerprint

Microarrays
Complex Mixtures
Toxicity
Water resources
Water supply
Gene expression
Rats
Complementary DNA
Genes
Tissue
Water

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Energy(all)

Cite this

Arnold, R. G., Turney, K. D., & Scholz, M. (2001). In vitro measurement of chemical toxicity in complex mixtures. In ACS Division of Environmental Chemistry, Preprints (1 ed., Vol. 41, pp. 1008-1010)

In vitro measurement of chemical toxicity in complex mixtures. / Arnold, Robert G; Turney, Karen D.; Scholz, Matthew.

ACS Division of Environmental Chemistry, Preprints. Vol. 41 1. ed. 2001. p. 1008-1010.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Arnold, RG, Turney, KD & Scholz, M 2001, In vitro measurement of chemical toxicity in complex mixtures. in ACS Division of Environmental Chemistry, Preprints. 1 edn, vol. 41, pp. 1008-1010, 221st ACS National Meeting, San Diego, CA, United States, 4/1/01.
Arnold RG, Turney KD, Scholz M. In vitro measurement of chemical toxicity in complex mixtures. In ACS Division of Environmental Chemistry, Preprints. 1 ed. Vol. 41. 2001. p. 1008-1010
Arnold, Robert G ; Turney, Karen D. ; Scholz, Matthew. / In vitro measurement of chemical toxicity in complex mixtures. ACS Division of Environmental Chemistry, Preprints. Vol. 41 1. ed. 2001. pp. 1008-1010
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