In vitro model to compare the oxygen offloading behaviour of dodecafluoropentane emulsion (DDFPe)

Meghna S. Jayaraman, Kaitlin Graham, Evan C Unger

Research output: Contribution to journalArticle

Abstract

The aim of this paper was to create an in vitro setup to quantify the oxygen offloading capabilities of dodecafluoropentane emulsion (DDFPe) in a hypoxic environment. Oxygen offloading from DDFPe was characterized under different gaseous environments and under pre-oxygenated conditions. Results of this study showed that (1) oxygen offloading is inversely related to the solubility of the selected sparging gas in saline and (2) both pre-oxygenated and simultaneously oxygenated DDFPe display similar magnitudes of oxygen transport. These results could be applicable to on-going and future studies involving a variety of hypoxic conditions where oxygen delivery might be therapeutically beneficial.

Original languageEnglish (US)
Pages (from-to)783-789
Number of pages7
JournalArtificial Cells, Nanomedicine and Biotechnology
Volume47
Issue number1
DOIs
StatePublished - Dec 4 2019
Externally publishedYes

Keywords

  • Dodecafluoropentane
  • in vitro model
  • oxygen therapeutic
  • perfluorocarbon
  • pre-oxygenation

ASJC Scopus subject areas

  • Biotechnology
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Pharmaceutical Science

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