In Vitro Sensitivity of Cancer Cells to Antitumor Agents

Alois A. Gratwohl, Sydney E. Salmon, Anne W. Hamburger, Barbara Soehnlen, Brian G.M. Durie, David S Alberts, Thomas E. Moon

Research output: Contribution to journalLetter

Abstract

To the Editor: I admire the careful work presented in the recent article by Salmon and his co-workers,1 and I agree with the opinion expressed in the accompanying editorial2 that this article may have a profound effect on the treatment of cancer. The general statement of the authors, however, that the bioassay presented can identify drugs to which a patient's tumor is resistant, and thus can eliminate the need for empirical trials, is premature and dangerous. It may be correct for alkylating agents, and for adriamycin and bleomycin. Their data pertain to these drugs. The authors include methotrexate in their. No extract is available for articles shorter than 400 words.

Original languageEnglish (US)
Pages (from-to)721
Number of pages1
JournalNew England Journal of Medicine
Volume299
Issue number13
DOIs
StatePublished - Sep 28 1978

Fingerprint

Antineoplastic Agents
Salmon
Alkylating Agents
Bleomycin
Methotrexate
Biological Assay
Pharmaceutical Preparations
Doxorubicin
Neoplasms
In Vitro Techniques
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gratwohl, A. A., Salmon, S. E., Hamburger, A. W., Soehnlen, B., Durie, B. G. M., Alberts, D. S., & Moon, T. E. (1978). In Vitro Sensitivity of Cancer Cells to Antitumor Agents. New England Journal of Medicine, 299(13), 721. https://doi.org/10.1056/NEJM197809282991313

In Vitro Sensitivity of Cancer Cells to Antitumor Agents. / Gratwohl, Alois A.; Salmon, Sydney E.; Hamburger, Anne W.; Soehnlen, Barbara; Durie, Brian G.M.; Alberts, David S; Moon, Thomas E.

In: New England Journal of Medicine, Vol. 299, No. 13, 28.09.1978, p. 721.

Research output: Contribution to journalLetter

Gratwohl, AA, Salmon, SE, Hamburger, AW, Soehnlen, B, Durie, BGM, Alberts, DS & Moon, TE 1978, 'In Vitro Sensitivity of Cancer Cells to Antitumor Agents', New England Journal of Medicine, vol. 299, no. 13, pp. 721. https://doi.org/10.1056/NEJM197809282991313
Gratwohl AA, Salmon SE, Hamburger AW, Soehnlen B, Durie BGM, Alberts DS et al. In Vitro Sensitivity of Cancer Cells to Antitumor Agents. New England Journal of Medicine. 1978 Sep 28;299(13):721. https://doi.org/10.1056/NEJM197809282991313
Gratwohl, Alois A. ; Salmon, Sydney E. ; Hamburger, Anne W. ; Soehnlen, Barbara ; Durie, Brian G.M. ; Alberts, David S ; Moon, Thomas E. / In Vitro Sensitivity of Cancer Cells to Antitumor Agents. In: New England Journal of Medicine. 1978 ; Vol. 299, No. 13. pp. 721.
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