In vivo acoustoelectric imaging for high-resolution visualization of cardiac electric spatiotemporal dynamics

Alexander Alvarez, Chet Preston, Teodoro Trujillo, Cameron Wilhite, Alex Burton, Sonia Vohnout, Russell S. Witte

Research output: Contribution to journalArticlepeer-review

Abstract

Acoustoelectric cardiac imaging (ACI) is a hybrid modality that exploits the interaction of an ultrasonic pressure wave and the resistivity of tissue to map current densities in the heart. This study demonstrates for the first time in vivo ACI in a swine model. ACI measured beat-to-beat variability (n = 20) of the peak of the cardiac activation wave at one location of the left ventricle as 5.32 ± 0.74 µV, 3.26 ± 0.54 mm below the epicardial surface, and 2.67 ± 0.56 ms before the peak of the local electrogram. Cross-sectional ACI images exhibited propagation velocities of 0.192 ± 0.061 m/s along the epicardial–endocardial axis with an SNR of 24.9 dB. This study demonstrates beat-to-beat and multidimensional ACI, which might reveal important information to help guide electroanatomic mapping procedures during ablation therapy.

Original languageEnglish (US)
JournalApplied optics
Volume59
Issue number36
DOIs
StatePublished - Dec 20 2020

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Engineering (miscellaneous)
  • Electrical and Electronic Engineering

Fingerprint Dive into the research topics of 'In vivo acoustoelectric imaging for high-resolution visualization of cardiac electric spatiotemporal dynamics'. Together they form a unique fingerprint.

Cite this