In vivo comparison of epithelial responses for S-8 versus JP-8 jet fuels below permissible exposure limit

Simon S. Wong, Jason Vargas, Alana Thomas, Cindy Fastje, Michael McLaughlin, Ryan Camponovo, R. Clark Lantz, Jeffrey Heys, Mark L. Witten

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

This study was designed to characterize and compare the pulmonary effects in distal lung from a low-level exposure to jet propellant-8 fuel (JP-8) and a new synthetic-8 fuel (S-8). It is hypothesized that both fuels have different airway epithelial deposition and responses. Consequently, male C57BL/6 mice were nose-only exposed to S-8 and JP-8 at average concentrations of 53 mg/m3 for 1 h/day for 7 days. A pulmonary function test performed 24 h after the final exposure indicated that there was a significant increase in expiratory lung resistance in the S-8 mice, whereas JP-8 mice had significant increases in both inspiratory and expiratory lung resistance compared to control values. Neither significant S-8 nor JP-8 respiratory permeability changes were observed compared to controls, suggesting no loss of epithelial barrier integrity. Morphological examination and morphometric analysis of airway tissue demonstrated that both fuels showed different patterns of targeted epithelial cells: bronchioles in S-8 and alveoli/terminal bronchioles in JP-8. Collectively, our data suggest that both fuels may have partially different deposition patterns, which may possibly contribute to specific different adverse effects in lung ventilatory function.

Original languageEnglish (US)
Pages (from-to)106-111
Number of pages6
JournalToxicology
Volume254
Issue number1-2
DOIs
StatePublished - Dec 5 2008

Keywords

  • Epithelial injury
  • Inhalation
  • Jet fuel
  • Lung resistance
  • Morphometry
  • Respiratory permeability

ASJC Scopus subject areas

  • Toxicology

Fingerprint Dive into the research topics of 'In vivo comparison of epithelial responses for S-8 versus JP-8 jet fuels below permissible exposure limit'. Together they form a unique fingerprint.

Cite this