In vivo intestinal calcium transport in infant rats: Normal and growth retarded

M. K. Younoszai, F. K. Ghishan

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

The authors compared the in vivo transport of calcium (Ca) in the jejunum + ileum of 1-, 2-, 3-, 4-, and 6-week old rats. In normal rats, net absorption and the estimated bidirectional fluxes of Ca (lumen-to-mucosa and mucosa-to-lumen) normalized for differences in size of the intestine (μmoles/hour per g weight) were similar in the 1-, 2-, and 3-week old rats and significantly lower in the 6-week old than in the younger rats. Growth retardation (pups raised with mothers fed a diet deficient in protein) appeared to have suppressed net absorption and the bidirectional fluxes of calcium in the 4- and 6-week old rats, but to have slightly enhanced net absorption and the bidirectional fluxes in the 1-, 2-, and 3-week old rats. These findings suggested a change in the mechanism(s) for intestinal transport of Ca during maturation. Rate of gain in body weight expressed as g/day increased with age from 1.4 g/day between 1 and 2 weeks, to 6.1 g/day between 4 and 6 weeks of age. There was no correlation between rate of net Ca absorption from the jejunum + ileum and gain in body weight expressed as g/day or as percent per day.

Original languageEnglish (US)
Pages (from-to)573-579
Number of pages7
JournalJournal of Nutrition
Volume109
Issue number4
DOIs
StatePublished - Jan 1 1979
Externally publishedYes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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