In vivo intestinal zinc transport in rats: Normal and growth retarded

Raymond Meneely, Fayez K Ghishan

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We compared the in vivo transport of zinc in segments of jejunum, ileum, and colon of 2-week-old (suckling) and 6-week-old (adolescent) rats. In normal rats, net absorption and lumen to mucosa flux of zinc, normalized for differences in size of the intestine (μmol/h/g dry weight) were significantly greater in all perfused segments of the suckling compared with corresponding segments of the adolescent rats (p < 0.05). Moreover, zinc transport rates in colonic segments of the suckling rats were significantly greater than corresponding transport rates in the small intestinal segments (p < 0.05). In the adolescent rats, transport rates in the colonic segments were similar to corre-sponding rates in the small intestinal segments. Growth retardation (pups raised with mothers fed a diet deficient in protein) appeared to have no effect on net absorption or lumen to mucosa flux of zinc in suckling rats, but significantly enhanced net absorption and lumen to mucosa flux of zinc in the adolescent rats.

Original languageEnglish (US)
Pages (from-to)119-124
Number of pages6
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume1
Issue number1
StatePublished - 1982
Externally publishedYes

Fingerprint

Zinc
zinc
suckling
rats
Growth
mucosa
Mucous Membrane
Jejunum
jejunum
Ileum
ileum
pups
growth retardation
colon
Intestines
Colon
intestines
Mothers
Diet
Weights and Measures

Keywords

  • Maturation of rats
  • Small and large intestine
  • Zinc transport

ASJC Scopus subject areas

  • Gastroenterology
  • Pediatrics, Perinatology, and Child Health
  • Food Science
  • Medicine (miscellaneous)
  • Histology

Cite this

In vivo intestinal zinc transport in rats : Normal and growth retarded. / Meneely, Raymond; Ghishan, Fayez K.

In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 1, No. 1, 1982, p. 119-124.

Research output: Contribution to journalArticle

@article{d98b4b9950e34fab99fcab8ad0f08626,
title = "In vivo intestinal zinc transport in rats: Normal and growth retarded",
abstract = "We compared the in vivo transport of zinc in segments of jejunum, ileum, and colon of 2-week-old (suckling) and 6-week-old (adolescent) rats. In normal rats, net absorption and lumen to mucosa flux of zinc, normalized for differences in size of the intestine (μmol/h/g dry weight) were significantly greater in all perfused segments of the suckling compared with corresponding segments of the adolescent rats (p < 0.05). Moreover, zinc transport rates in colonic segments of the suckling rats were significantly greater than corresponding transport rates in the small intestinal segments (p < 0.05). In the adolescent rats, transport rates in the colonic segments were similar to corre-sponding rates in the small intestinal segments. Growth retardation (pups raised with mothers fed a diet deficient in protein) appeared to have no effect on net absorption or lumen to mucosa flux of zinc in suckling rats, but significantly enhanced net absorption and lumen to mucosa flux of zinc in the adolescent rats.",
keywords = "Maturation of rats, Small and large intestine, Zinc transport",
author = "Raymond Meneely and Ghishan, {Fayez K}",
year = "1982",
language = "English (US)",
volume = "1",
pages = "119--124",
journal = "Journal of Pediatric Gastroenterology and Nutrition",
issn = "0277-2116",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - In vivo intestinal zinc transport in rats

T2 - Normal and growth retarded

AU - Meneely, Raymond

AU - Ghishan, Fayez K

PY - 1982

Y1 - 1982

N2 - We compared the in vivo transport of zinc in segments of jejunum, ileum, and colon of 2-week-old (suckling) and 6-week-old (adolescent) rats. In normal rats, net absorption and lumen to mucosa flux of zinc, normalized for differences in size of the intestine (μmol/h/g dry weight) were significantly greater in all perfused segments of the suckling compared with corresponding segments of the adolescent rats (p < 0.05). Moreover, zinc transport rates in colonic segments of the suckling rats were significantly greater than corresponding transport rates in the small intestinal segments (p < 0.05). In the adolescent rats, transport rates in the colonic segments were similar to corre-sponding rates in the small intestinal segments. Growth retardation (pups raised with mothers fed a diet deficient in protein) appeared to have no effect on net absorption or lumen to mucosa flux of zinc in suckling rats, but significantly enhanced net absorption and lumen to mucosa flux of zinc in the adolescent rats.

AB - We compared the in vivo transport of zinc in segments of jejunum, ileum, and colon of 2-week-old (suckling) and 6-week-old (adolescent) rats. In normal rats, net absorption and lumen to mucosa flux of zinc, normalized for differences in size of the intestine (μmol/h/g dry weight) were significantly greater in all perfused segments of the suckling compared with corresponding segments of the adolescent rats (p < 0.05). Moreover, zinc transport rates in colonic segments of the suckling rats were significantly greater than corresponding transport rates in the small intestinal segments (p < 0.05). In the adolescent rats, transport rates in the colonic segments were similar to corre-sponding rates in the small intestinal segments. Growth retardation (pups raised with mothers fed a diet deficient in protein) appeared to have no effect on net absorption or lumen to mucosa flux of zinc in suckling rats, but significantly enhanced net absorption and lumen to mucosa flux of zinc in the adolescent rats.

KW - Maturation of rats

KW - Small and large intestine

KW - Zinc transport

UR - http://www.scopus.com/inward/record.url?scp=0019941434&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019941434&partnerID=8YFLogxK

M3 - Article

C2 - 7186020

AN - SCOPUS:0019941434

VL - 1

SP - 119

EP - 124

JO - Journal of Pediatric Gastroenterology and Nutrition

JF - Journal of Pediatric Gastroenterology and Nutrition

SN - 0277-2116

IS - 1

ER -