In vivo intestinal zinc transport in rats: Normal and growth retarded

Raymond Meneely, Fayez K. Ghishan

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

We compared the in vivo transport of zinc in segments of jejunum, ileum, and colon of 2-week-old (suckling) and 6-week-old (adolescent) rats. In normal rats, net absorption and lumen to mucosa flux of zinc, normalized for differences in size of the intestine (μmol/h/g dry weight) were significantly greater in all perfused segments of the suckling compared with corresponding segments of the adolescent rats (p < 0.05). Moreover, zinc transport rates in colonic segments of the suckling rats were significantly greater than corresponding transport rates in the small intestinal segments (p < 0.05). In the adolescent rats, transport rates in the colonic segments were similar to corre-sponding rates in the small intestinal segments. Growth retardation (pups raised with mothers fed a diet deficient in protein) appeared to have no effect on net absorption or lumen to mucosa flux of zinc in suckling rats, but significantly enhanced net absorption and lumen to mucosa flux of zinc in the adolescent rats.

Original languageEnglish (US)
Pages (from-to)119-124
Number of pages6
JournalJournal of pediatric gastroenterology and nutrition
Volume1
Issue number1
DOIs
StatePublished - Jan 1 1982
Externally publishedYes

Keywords

  • Maturation of rats
  • Small and large intestine
  • Zinc transport

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Gastroenterology

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