Abstract
Summary: To compare the absolute risk of fracture to the risk of other conditions by race/ethnicity, we studied 83,724 women, aged 70-79. The projected number of fractures was similar to or exceeded the combined number of cardiovascular events and breast cancers. Osteoporosis prevention efforts should target women of all ethnicities. Introduction: The relative risk of fracture is lower in non-white compared to white women but the absolute risk of fracture in comparison to other common chronic conditions is uncertain. Methods: We performed a prospective cohort study of 83,724 women, age 50-79 years. Cardiovascular disease (CVD), invasive breast cancer and all fractures were identified over an average of 7.7 ± 2.6 years. Results: The incidence of fracture, breast cancer, stroke and CVD varied across ethnicity. The annualized (%) incidence of fracture was greatest in whites (2.4%) and American Indians (2.8%) and lowest among blacks (1.3%). The majority of hip fractures occurred in white women. The projected number of women who will experience a fracture in one year exceeded the combined number of women who would experience invasive breast cancer or a broad category of CVD events in all ethnic groups except blacks. In 10,000 black women, an estimated 153 women would experience CVD, and 35 women, breast cancer compared to 126 women expected to fracture in one year. Conclusion: The annual risk of suffering a fracture is substantial in women of all ethnicities. Osteoporosis prevention efforts should target all women irrespective of their race/ethnic backgrounds.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1717-1723 |
| Number of pages | 7 |
| Journal | Osteoporosis International |
| Volume | 19 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 2008 |
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Keywords
- Breast cancer
- Cardiovascular disease
- Fracture
- Osteoporosis
- Race/ethnicity
- Women's Health Initiative
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
Cite this
Incidence of fractures compared to cardiovascular disease and breast cancer : The Women's Health Initiative Observational Study. / Cauley, J. A.; Wampler, N. S.; Barnhart, J. M.; Wu, L.; Allison, M.; Chen, Zhao; Hendrix, S.; Robbins, J.; Jackson, R. D.
In: Osteoporosis International, Vol. 19, No. 12, 12.2008, p. 1717-1723.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Incidence of fractures compared to cardiovascular disease and breast cancer
T2 - The Women's Health Initiative Observational Study
AU - Cauley, J. A.
AU - Wampler, N. S.
AU - Barnhart, J. M.
AU - Wu, L.
AU - Allison, M.
AU - Chen, Zhao
AU - Hendrix, S.
AU - Robbins, J.
AU - Jackson, R. D.
PY - 2008/12
Y1 - 2008/12
N2 - Summary: To compare the absolute risk of fracture to the risk of other conditions by race/ethnicity, we studied 83,724 women, aged 70-79. The projected number of fractures was similar to or exceeded the combined number of cardiovascular events and breast cancers. Osteoporosis prevention efforts should target women of all ethnicities. Introduction: The relative risk of fracture is lower in non-white compared to white women but the absolute risk of fracture in comparison to other common chronic conditions is uncertain. Methods: We performed a prospective cohort study of 83,724 women, age 50-79 years. Cardiovascular disease (CVD), invasive breast cancer and all fractures were identified over an average of 7.7 ± 2.6 years. Results: The incidence of fracture, breast cancer, stroke and CVD varied across ethnicity. The annualized (%) incidence of fracture was greatest in whites (2.4%) and American Indians (2.8%) and lowest among blacks (1.3%). The majority of hip fractures occurred in white women. The projected number of women who will experience a fracture in one year exceeded the combined number of women who would experience invasive breast cancer or a broad category of CVD events in all ethnic groups except blacks. In 10,000 black women, an estimated 153 women would experience CVD, and 35 women, breast cancer compared to 126 women expected to fracture in one year. Conclusion: The annual risk of suffering a fracture is substantial in women of all ethnicities. Osteoporosis prevention efforts should target all women irrespective of their race/ethnic backgrounds.
AB - Summary: To compare the absolute risk of fracture to the risk of other conditions by race/ethnicity, we studied 83,724 women, aged 70-79. The projected number of fractures was similar to or exceeded the combined number of cardiovascular events and breast cancers. Osteoporosis prevention efforts should target women of all ethnicities. Introduction: The relative risk of fracture is lower in non-white compared to white women but the absolute risk of fracture in comparison to other common chronic conditions is uncertain. Methods: We performed a prospective cohort study of 83,724 women, age 50-79 years. Cardiovascular disease (CVD), invasive breast cancer and all fractures were identified over an average of 7.7 ± 2.6 years. Results: The incidence of fracture, breast cancer, stroke and CVD varied across ethnicity. The annualized (%) incidence of fracture was greatest in whites (2.4%) and American Indians (2.8%) and lowest among blacks (1.3%). The majority of hip fractures occurred in white women. The projected number of women who will experience a fracture in one year exceeded the combined number of women who would experience invasive breast cancer or a broad category of CVD events in all ethnic groups except blacks. In 10,000 black women, an estimated 153 women would experience CVD, and 35 women, breast cancer compared to 126 women expected to fracture in one year. Conclusion: The annual risk of suffering a fracture is substantial in women of all ethnicities. Osteoporosis prevention efforts should target all women irrespective of their race/ethnic backgrounds.
KW - Breast cancer
KW - Cardiovascular disease
KW - Fracture
KW - Osteoporosis
KW - Race/ethnicity
KW - Women's Health Initiative
UR - http://www.scopus.com/inward/record.url?scp=55049106644&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=55049106644&partnerID=8YFLogxK
U2 - 10.1007/s00198-008-0634-y
DO - 10.1007/s00198-008-0634-y
M3 - Article
C2 - 18629572
AN - SCOPUS:55049106644
VL - 19
SP - 1717
EP - 1723
JO - Osteoporosis International
JF - Osteoporosis International
SN - 0937-941X
IS - 12
ER -