Incidence, prevalence, and clearance of type-specific human papillomavirus infections: The Young Women's Health Study

Anna R. Giuliano, Robin Harris, Rebecca L. Sedjo, Susie Baldwin, Denise Roe, Mary R. Papenfuss, Martha Abrahamsen, Paula Inserra, Sandra Olvera, Kenneth Hatch

Research output: Contribution to journalArticle

230 Scopus citations

Abstract

The natural history of type-specific human papillomavirus (HPV) infections was examined in a cohort of 331 Women aged 18-35 years who self-referred for routine gynecological care. Participants underwent a gynecological examination at baseline and at ∼4 and ∼10 months after baseline. Cervical samples were collected for HPV testing and genotyping at each visit, as was information on reproductive, sexual, and medical histories. The rate of new HPV infections was 2.9% per month; the highest rates were observed for HPV types 16, 39, 84, and 51. Among women who tested negative for HPV at baseline, the cumulative probability of acquiring an oncogenic HPV strain during a 12-month follow-up period was 0.32, compared with 0.18 for nononcogenic strains. Women who had had ≥ 1 new male sex partner in the recent past were significantly more likely to acquire a new HPV infection (relative hazard, 2.39; 95% confidence interval, 1.20-4.76). The median time to clearance of infection was significantly longer for oncogenic strains (9.8 months) than for nononcogenic strains (4.3 months).

Original languageEnglish (US)
Pages (from-to)462-469
Number of pages8
JournalJournal of Infectious Diseases
Volume186
Issue number4
DOIs
StatePublished - Aug 15 2002

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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