Uvelichenie aktivnosti ornitindekarboksilazy i soderzhaniia poliaminov v pecheni krys v ranniǐ period gepatokantserogeneza.

Translated title of the contribution: Increase in ornithine decarboxylase activity and polyamine levels of the rat liver during an early period of hepatocarcinogenesis

N. K. Berdinskikh, S. P. Zaletok, N. A. Ignatenko, N. V. Draga

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The ornithine decarboxylase activity and the polyamine content in the fraction of plasma membranes and cytosol of the rat liver are studied in the early period (1-4 weeks) of nitrosodiethyl amine-induced hepatocarcinogenesis. The enzyme activity and polyamine levels in the cytosol of the rat liver cells are found to increase sharply during the first month of the disease, the maximum being observed the first-second week. By the end of the fourth week these indices become lower but they remain significantly higher than the normal levels. The polyamine level increases considerably in the fraction of plasma membranes with the maximum observed the second week.

Translated title of the contributionIncrease in ornithine decarboxylase activity and polyamine levels of the rat liver during an early period of hepatocarcinogenesis
Original languageRussian
Pages (from-to)94-97
Number of pages4
JournalUkrainskii biokhimicheskii zhurnal
Volume60
Issue number1
StatePublished - Jan 1 1988
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry

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