Increase in ornithine decarboxylase activity associated with development of dysplasia in barrett's esophagus

Harinder S. Garewal, Richard Sampliner, David S Alberts, Karen Steinbronn

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

A case of Barrett's esophagus of the specialized columnar type is described in which mucosal ornithine decarboxylase levels were measured in endoscopic biopsies at two intervals over which severe dysplasia had developed. The Barrett's mucosa extended 5 cm above the gastroesophageal junction, was free of dysplasia, and had no detectable ornithine decarboxylase activity at initial evaluation. On follow-up endoscopy one year later, the Barrett's mucosa had become dysplastic with a markedly elevated ornithine decarboxylase activity of 1.56 units/mg protein. The patient underwent an esophagectomy because of persistent severe dysplasia and continues to do well postoperatively. Elevated ornithine decarboxylase activity has been described in other premalignant conditions, especially when dysplasia has been present. Further studies in Barrett's esophagus are warranted, since ODC activity might prove to be a useful biochemical marker for dysplasia and increased cancer risk.

Original languageEnglish (US)
Pages (from-to)312-314
Number of pages3
JournalDigestive Diseases and Sciences
Volume34
Issue number2
DOIs
StatePublished - Feb 1989

Fingerprint

Ornithine Decarboxylase
Barrett Esophagus
Mucous Membrane
Esophagogastric Junction
Esophagectomy
Endoscopy
Biomarkers
Biopsy
Neoplasms
Proteins

Keywords

  • Barrett's esophagus
  • dysplasia
  • ornithine decarboxylase

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Increase in ornithine decarboxylase activity associated with development of dysplasia in barrett's esophagus. / Garewal, Harinder S.; Sampliner, Richard; Alberts, David S; Steinbronn, Karen.

In: Digestive Diseases and Sciences, Vol. 34, No. 2, 02.1989, p. 312-314.

Research output: Contribution to journalArticle

Garewal, Harinder S. ; Sampliner, Richard ; Alberts, David S ; Steinbronn, Karen. / Increase in ornithine decarboxylase activity associated with development of dysplasia in barrett's esophagus. In: Digestive Diseases and Sciences. 1989 ; Vol. 34, No. 2. pp. 312-314.
@article{95541c5052ca4c51916589e51bbd364c,
title = "Increase in ornithine decarboxylase activity associated with development of dysplasia in barrett's esophagus",
abstract = "A case of Barrett's esophagus of the specialized columnar type is described in which mucosal ornithine decarboxylase levels were measured in endoscopic biopsies at two intervals over which severe dysplasia had developed. The Barrett's mucosa extended 5 cm above the gastroesophageal junction, was free of dysplasia, and had no detectable ornithine decarboxylase activity at initial evaluation. On follow-up endoscopy one year later, the Barrett's mucosa had become dysplastic with a markedly elevated ornithine decarboxylase activity of 1.56 units/mg protein. The patient underwent an esophagectomy because of persistent severe dysplasia and continues to do well postoperatively. Elevated ornithine decarboxylase activity has been described in other premalignant conditions, especially when dysplasia has been present. Further studies in Barrett's esophagus are warranted, since ODC activity might prove to be a useful biochemical marker for dysplasia and increased cancer risk.",
keywords = "Barrett's esophagus, dysplasia, ornithine decarboxylase",
author = "Garewal, {Harinder S.} and Richard Sampliner and Alberts, {David S} and Karen Steinbronn",
year = "1989",
month = "2",
doi = "10.1007/BF01536068",
language = "English (US)",
volume = "34",
pages = "312--314",
journal = "Digestive Diseases and Sciences",
issn = "0163-2116",
publisher = "Plenum Publishers",
number = "2",

}

TY - JOUR

T1 - Increase in ornithine decarboxylase activity associated with development of dysplasia in barrett's esophagus

AU - Garewal, Harinder S.

AU - Sampliner, Richard

AU - Alberts, David S

AU - Steinbronn, Karen

PY - 1989/2

Y1 - 1989/2

N2 - A case of Barrett's esophagus of the specialized columnar type is described in which mucosal ornithine decarboxylase levels were measured in endoscopic biopsies at two intervals over which severe dysplasia had developed. The Barrett's mucosa extended 5 cm above the gastroesophageal junction, was free of dysplasia, and had no detectable ornithine decarboxylase activity at initial evaluation. On follow-up endoscopy one year later, the Barrett's mucosa had become dysplastic with a markedly elevated ornithine decarboxylase activity of 1.56 units/mg protein. The patient underwent an esophagectomy because of persistent severe dysplasia and continues to do well postoperatively. Elevated ornithine decarboxylase activity has been described in other premalignant conditions, especially when dysplasia has been present. Further studies in Barrett's esophagus are warranted, since ODC activity might prove to be a useful biochemical marker for dysplasia and increased cancer risk.

AB - A case of Barrett's esophagus of the specialized columnar type is described in which mucosal ornithine decarboxylase levels were measured in endoscopic biopsies at two intervals over which severe dysplasia had developed. The Barrett's mucosa extended 5 cm above the gastroesophageal junction, was free of dysplasia, and had no detectable ornithine decarboxylase activity at initial evaluation. On follow-up endoscopy one year later, the Barrett's mucosa had become dysplastic with a markedly elevated ornithine decarboxylase activity of 1.56 units/mg protein. The patient underwent an esophagectomy because of persistent severe dysplasia and continues to do well postoperatively. Elevated ornithine decarboxylase activity has been described in other premalignant conditions, especially when dysplasia has been present. Further studies in Barrett's esophagus are warranted, since ODC activity might prove to be a useful biochemical marker for dysplasia and increased cancer risk.

KW - Barrett's esophagus

KW - dysplasia

KW - ornithine decarboxylase

UR - http://www.scopus.com/inward/record.url?scp=0024589505&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024589505&partnerID=8YFLogxK

U2 - 10.1007/BF01536068

DO - 10.1007/BF01536068

M3 - Article

VL - 34

SP - 312

EP - 314

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

SN - 0163-2116

IS - 2

ER -