Increased carbon monoxide production by hemeoxygenase-1 caused by device-mediated hemolysis: Thrombotic phantom menace?

Vance G Nielsen, Ellen C. Pearson, M. Cristina Smith

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Replacement of key components of the circulatory system with artificial devices has become the mainstay of therapy for conditions such as end-stage valvular disease or congestive heart failure. Unfortunately, device thrombosis and thromboembolic morbidity persist despite optimized anticoagulation. This work reviews the commonly known causes of device-associated thrombophilia, introduces recent literature concerning the effect of carbon monoxide on coagulation, and presents new patient data linking endogenously produced carbon monoxide with device-associated thrombosis. A new paradigm involving the interaction of red blood cell lysis-induced upregulation of hemoxygenase-1, increased endogenous carbon monoxide, hyperfibrinogenemia, and contact protein/microparticle-induced thrombin generation is presented.

Original languageEnglish (US)
Pages (from-to)1008-1014
Number of pages7
JournalArtificial Organs
Volume37
Issue number11
DOIs
StatePublished - Nov 2013

Fingerprint

Heme Oxygenase-1
Carbon Monoxide
Hemolysis
Carbon monoxide
Equipment and Supplies
Thrombosis
Coagulation
Thrombin
Thrombophilia
Blood
Cardiovascular System
Cells
Proteins
Up-Regulation
Heart Failure
Erythrocytes
Morbidity
Therapeutics

Keywords

  • Carbon monoxide
  • Hemeoxygenase-1
  • Hemolysis
  • Prosthetic heart valve
  • Thromboembolism
  • Total artificial heart
  • Ventricular assist device

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Bioengineering
  • Medicine (miscellaneous)

Cite this

Increased carbon monoxide production by hemeoxygenase-1 caused by device-mediated hemolysis : Thrombotic phantom menace? / Nielsen, Vance G; Pearson, Ellen C.; Smith, M. Cristina.

In: Artificial Organs, Vol. 37, No. 11, 11.2013, p. 1008-1014.

Research output: Contribution to journalArticle

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