Increased cytochrome c correlates with poor survival in aggressive lymphoma

Saraht Wilkinson, David B.F. Johnson, Heather L. Tardif, Margaret E. Tome, Margaret M. Briehl

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Mitochondria are central to a variety of cellular processes, from metabolism to cell death. In this study, we demonstrated that an increase in the critical mitochondrial protein, cytochrome c, correlated with drug resistance in a cell culture model of aggressive lymphoma. Increased cytochrome c expression was also correlated with decreased survival in the aggressive diffuse large B-cell and mantle cell lymphomas, but not in the indolent follicular lymphoma. This suggests that an increased reliance on the mitochondria for energy allows tumor cells to be metabolic opportunists and contribute to tumor development and drug resistance.

Original languageEnglish (US)
Pages (from-to)227-230
Number of pages4
JournalOncology Letters
Volume1
Issue number2
DOIs
StatePublished - Mar 1 2010

Keywords

  • Cytochrome c
  • Diffuse large B-cell lymphoma
  • Follicular lymphoma
  • Gene expression profiling
  • Mantle-cell lymphoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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